CURRICULUM VITAE

日本語バージョン

 

Dr.Yamamoto

Name: Masaya Yamamoto
Nationality: Japan
Present Position: Assistant Professor

Work Address :

Department of Biomaterials, Field of Tissue Engineering,
Institute for Frontier Medical Sciences, Kyoto University
Address: 53 Kawara-cho Shogoin, Sakyo-ku, Kyoto 606-8507, Japan
Phone: +81-75-751-4108, Fax: +81-75-751-4646
Place of Birth: Osaka, Japan
Date of Birth: 24 May 1971

Education:

1994 B.Eng. Department of Polymer Chemistry, Faculty of Engineering, Kyoto University
1996 M.Eng. Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University
1999

Ph.D. Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University

Professional Positions:

1999-2000

Research Associate, Institute for Frontier Medical Sciences, Kyoto University
(Postdoctoral fellow, “Research for the Future” Program of the Japan Society for the Promotion of Science (JSPS))
1999

Visiting Scientist, Institute for Polymer Research, Dresden, Germany
(PI: Dr. Carsten Werner)
2000-2004

Instructor, Department of Biomaterials, Field of Tissue Engineering,
Institute for Frontier Medical Sciences, Kyoto University
2004-present

Assistant Professor, Department of Biomaterials, Field of Tissue Engineering,
Institute for Frontier Medical Sciences, Kyoto University
2002-2006

Researcher, Precursory Research for Embryonic Science and Technology (PRESTO),
Japan Science and Technology Agency (JST)
2007-2008

Visiting Fellow, Department of Genetic Medicine, Weill Medical College of Cornell University
(PI: Professor Shahin Rafii)

Awards and Honors:

2001.7

The 22nd Annual Meeting of the Japanese Society of Inflammation and Regeneration: Excellent Presentation Award
2001.7

The 5th Conference on Cardiovascular Disease Science: Young Scientist Award
2001.12

The Takeda Techno-Entrepreneurship Award 2004: Finalist Commendation
2005.7

The 26th Annual Meeting of the Japanese Society of Inflammation and Regeneration: Excellent Presentation Award
2006.2

The Nagaishi Award: Young Scientist Award on Biomedical Engineering (Awarded by Institute for Frontier Medical Sciences, Kyoto University)
2007.4

Research Fellowship: Kyoto University Foundation for Promotion of Education and Research

Research Interests:

Biomaterial, Tissue Engineering, Drug Delivery System, Stem Cell Biology
Basic researches on biomaterials for basic medicine and biology as well as clinical medicine. Our research goal is to positively apply the basic research results on biomaterials to tissue engineering, drug delivery system, and stem cell biology. Recent research interests: Stem cell manipulation by biomaterial-based artificial extracellular environments.

List of Publications:

  1. K. Kato, M. Yamamoto, and Y. Ikada, Ultrastructure of the interface between cultured osteoblasts and polymer substrates carrying organophosphate graft chains, " Bioceramics 9 ", T. Kokubo ed., Elsevier Science LTD, Oxford, 1996, pp. 383-386.
  2. M. Yamamoto, K. Kato, and Y. Ikada, Effect of the structure of bone morphogenetic protein carriers on ectopic bone regeneration, Tissue Engineering, 2(4), 315-326 (1996).
  3. M. Yamamoto, K. Kato, and Y. Ikada, Ultrastructure of the interface between cultured osteoblasts and surface-modified polymer substrates, J. Biomed. Mater. Res., 37(1), 29-36 (1997).
  4. L. Hong, Y. Tabata, M. Yamamoto, S. Miyamoto, K. Yamada, N. Hashimoto, and Y. Ikada, Comparison of bone regeneration by bone morphogenetic protein incorporated in biodegradable hydrogel and in solution, J. Biomater. Sci. Polym. Edn., 9(9), 1001-1014 (1998).
  5. Y. Tabata, M. Yamamoto, and Y. Ikada, Biodegradable hydrogels for bone regeneration through growth factor release, Pure and Appl. Chem., 70(6), 1277-1282 (1998).
  6. M. Yamamoto, Y. Tabata, and Y. Ikada, Ectopic bone formation induced by biodegradable hydrogels incorporating bone morphogenetic protein, J. Biomater. Sci. Polym. Edn., 9(5), 439-458 (1998).
  7. Y. Tabata, M. Yamamoto, and Y. Ikada, Comparison of release profiles of various growth factors from biodegradable carriers, Mat. Res. Soc. Symp. Proc., 530, R. C. Thomson, D. J. Mooney, K. E. Healy, Y. Ikada, and A. G. Mikos eds., Material Research Society, Pennsylvania, 1998, pp. 13-18.
  8. Y. Tabata, M. Miyao, M. Yamamoto, and Y. Ikada, Vascularization into porous sponge by sustained release of basic fibroblast growth factor, J. Biomater. Sci. Polym. Edn., 10(9), 957-968 (1999).
  9. M. Yamamoto, Y. Tabata, and Y. Ikada, Growth factor release from gelatin hydrogel for tissue engineering, J. Bioact. Compat. Polym., 14(6), 474-489 (1999).
  10. M. Yamamoto, Y. Tabata, L. Hong, S. Miyamoto, N. Hashimoto, and Y. Ikada, Bone regeneration by transforming growth factor b1 released from a biodegradable hydrogel, J. Controlled Release 64, 133-142 (2000).
  11. L. Hong, Y. Tabata, S. Miyamoto, M. Yamamoto, K. Yamada, N. Hashimoto, and Y. Ikada, Bone regeneration at rabbit skull defects treated with transforming growth factor-b1 incorporated into hydrogels with different levels of biodegradability, J. Neurosurg., 92(2), 315-325 (2000).
  12. M. Yamamoto, Y. Tabata, H. Kawasaki, and Y. Ikada, Promotion of fibrovascular tissue ingrowth into porous sponges by basic fibroblast growth factor, J. Mater. Res., Materials in Medicine, 11, 213-218 (2000).
  13. K. Kato, Y. Kikumura, M. Yamamoto, N. Tomita, S. Yamada, and Y. Ikada, Collagen immobilization onto the surface of artificial hair for improving the tissue adhesion, J. Adhens. Sci. Technol., 14(5), 635-650 (2000).
  14. M. Yamamoto, Y. Ikada, and Y. Tabata, Controlled release of growth factors based on biodegradation of gelatin hydrogel, J. Biomater. Sci. Polym. Edn., 12(1), 77-88 (2001).
  15. H. Ueda, L. Hong, M. Yamamoto, K. Shigeno, M. Inoue, T. Toba, M. Yoshitani, T. Nakamura, Y. Tabata, and Y. Shimizu, Use of collagen sponge impregnated with transforming growth factor b1 to promote bone repair in skull defects in rabbits, Biomaterials, 23(4), 1003-1010 (2001).
  16. Y. Sakakibara, K. Nishimura, K. Tambara, M. Yamamoto, F. Lu, Y. Tabata, and M. Komeda, Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation, J. Thorac. Cardiovasc. Surg., 124(1), 50-56 (2002).
  17. T. Okamoto, Y. Yamamoto, M. Gotoh, D. Liu, M. Kihara, K. Kameyama, E. Hayashi, K. Nakamura, A. Yamauchi, C.-L. Huang, H. Yokomise, M. Yamamoto, T. Nakamura, Y. Shimizu, and Y. Tabata, Cartilage regeneration using slow release of bone morphogenetic protein-2 from a gelatin sponge to treat experimental canine tracheomalacia: A preliminary report, ASAIO J., 49, 63-69 (2003).
  18. M. Yamamoto, Y. Sakakibara, K. Nishimura, M. Komeda, and Y. Tabata, Improved therapeutic efficacy in cardiomyocyte transplantation for myocardial infarction with release system of basic fibroblast growth factor, Artif. Organ, 27(2), 181-198 (2003).
  19. H. Ueda, T. Nakamura, M. Yamamoto, N. Nagata, S. Fukuda, Y. Tabata, and Y. Shimizu, Repairing of rabbit skull defect by dehydrothermally crosslinked collagen sponges incorporating transforming growth factor b1, J. Controlled Release, 88, 55-64 (2003).
  20. Y. Sakakibara, K. Tambara, G. Sakaguchi, F. Lu, M. Yamamoto, K. Nishimura, Y. Tabata, and M. Komeda, Toward surgical angiogenesis using slow-released basic fibroblast growth factor, Eur. J. Cardio-thoracic. Surg., 24, 105-112 (2003).
  21. M. Yamamoto, Y. Takahashi, and Y. Tabata, Controlled release of bone morphogenetic protein by biodegradable hydrogels induces the promoted osteoinductive effect, Biomaterials, 24(24), 4375-4383 (2003).
  22. Y. Yamamoto, T. Okamoto, M. Goto, H. Yokomise, M. Yamamoto, and Y. Tabata, Experimental study of bone morphogenetic protein-2 slow release from an artificial trachea made of biodegradable materials: evaluation of stenting time, ASAIO J., 49, 533-536 (2003).
  23. H. Takita, J. W.M. Vehof, J. A. Jansen, M. Yamamoto, Y. Tabata, M. Tamura, and Y. Kuboki, Carrier dependent cell differentiation of bone morphogenetic protein-2 induced osteogenesis and chondrogenesis during the early implantation stage in rats, J. Biomed. Mater. Res., 71A, 181-189 (2004).
  24. A. Kanematsu, A. Marui, S. Yamamoto, M. Ozeki, Y. Hirano, M. Yamamoto, O. Ogawa, M. Komeda, and Y. Tabata, Type I collagen can function as a reservoir of basic fibroblast growth factor, J. Control. Release, 99(2), 281-292 (2004).
  25. T. Ishimoto, T. Nakano, Y. Umakoshi, M. Yamamoto, Y. Tabata, Effects of applied stress on preferential alignment of biological apatite in rabbit forelimb bones, Phosphorus Research Bulletin, 17, 77-82 (2004).
  26. M. Yamamoto, Y. Takahashi, and Y. Tabata, Bone induction by controlled release of BMP-2 from a biodegradable hydrogel in various animal species -From mouse to non-human primate-, Key Engineering Materials, 288-289, 253-256 (2005).
  27. Y. Takahashi, M. Yamamoto, and Y. Tabata, Osteogenic differentiation of mesenchymal stem cells in biodegradable sponges composed of gelatin and b-tricalcium phosphate, Biomaterials, 26(17), 3587-3596 (2005).
  28. Y. Takahashi, M. Yamamoto, and Y. Tabata, Enhanced osteoinduction by controlled release of bone morphogenetic protein-2 from biodegradable sponges composed of gelatin and b-tricalcium phosphate, Biomaterials, 26(23), 4856-4865 (2005).
  29. G. Sakaguchi, K. Tambara, Y. Sakakibara, M. Ozeki, M. Yamamoto, G.. Premaratne, X. Lin, K. Hasegawa, Y. Tabata, K. Nishimura, and M. Komeda, Control-released hepatocyte growth factor prevents the progression of heart failure in stroke-prone spontaneously hypertensive rats, Ann. Thorac. Surg., 79(5), 1627-1634 (2005).
  30. A. Marui, A. Kanematsu, K. Yamahara, K. Doi, T. Kushibiki, M. Yamamoto, H. Itoh, T. Ikeda, Y. Tabata, and M. Komeda, Simultaneous application of basic fibroblast growth factor and hepatocyte growth factor to enhance the blood vessels formation, J. Vasc. Surg., 41(1), 82-90 (2005).
  31. K. Tambara, G.. U. Premaratne, G.. Sakaguchi, N. Kanemitsu, X. Lin, H. Nakajima, Y. Sakakibara, Y. Kimura, M. Yamamoto, Y. Tabata, T. Ikeda, and M. Komeda, Administration of control-released hepatocyte growth factor enhances the efficacy of skeletal myoblast transplantation in rat infarcted hearts by greatly increasing both quantity and quality of the graft, Circulation, 112(9 Suppl), I129-I134 (2005).
  32. Y. Takahashi, M. Yamamoto, and Y. Tabata, Design of an osteoinductive biodegradable cell scaffold based on controlled release technology of bone morphogenetic protein, Israel J. Chem., 45(4), 465-475 (2005).
  33. M. Yamamoto, Y. Takahashi, A. Hokugo, and Y. Tabata, Enhanced osteoinduction by biodegradable gelatin-b-tricalcium phosphate sponge capable for bone morphogenetic protein release, J. Hard Tissue Biol., 14(2), 286-287 (2005).
  34. A. Marui, K. Doi, K. Tambara, Y. Sakakibara, K. Ueyama, A. Iwakura, M. Yamamoto, T. Ikeda, Y. Tabata, and M. Komeda, Basic fibroblast growth factor and angiogenesis, “Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches” (Mori, H. and Matsuda, H. Eds., Springer-Verlag, Tokyo), 145-156 (2005).
  35. J. Tazaki, T. Akazawa, M. Murata, M. Yamamoto, Y. Tabata, R. Yoshimoto, M. Arisue, BMP-2 dose-response and release studies in functionally graded HAp, Archives of Bioceramics Research, 5, 182-185 (2005).
  36. Y. Takahashi, M. Yamamoto, and Y. Tabata, Enhanced bone regeneration at a segmental bone defect by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel, Tissue Eng., 12(5), 1305-1311 (2006).
  37. H. Hosseinkhani, M. Yamamoto, Y. Inatsugu, Y. Hiraoka, S. Inoue, H. Shimokawa, and Y. Tabata, Enhanced ectopic bone formation using a combination of plasmid DNA impregnation into 3-D scaffold and bioreactor perfusion culture, Biomaterials, 27(8), 1387-1398 (2006).
  38. T. Nakano, T. Ishimoto, J.-W. Lee, Y. Umakoshi, M. Yamamoto, Y. Tabata, A. Kobayashi, H. Iwaki, K. Takaoka, M. Kawai, and T. Yamamoto, Crystallographic approach to regenerated and pathological hard tissues, Materials Science Forum, 512, 255-260 (2006).
  39. T. Ishimoto, T. Nakano, Y. Umakoshi, M. Yamamoto, Y. Tabata, Role of stress distribution on healing process of preferential alignment of biological apatite in long bones, Materials Science Forum, 512, 261-264 (2006).
  40. J.-W. Lee, T. Nakano, S. Toyosawa, N. Ijuhin, Y. Tabata, M. Yamamoto, and Y. Umakoshi, Role of osteoclast in preferential alignment of biological apatite (BAp) in long bones. Materials Science Forum, 512, 265-268 (2006).
  41. H. Igai, S.S. Chang, M. Gotoh, Y. Yamamoto, N. Misaki, T. Okamoto, M. Yamamoto, Y. Tabata, H. Yokomise, Regeneration of canine tracheal cartilage by slow release of basic fibroblast growth factor from gelatin sponge, ASAIO J., 52(1), 86-91 (2006).
  42. M. Yamamoto and Y. Tabata, Tissue Engineering by modulated gene delivery, Adv. Drug Deliv. Rev., 58(4), 535-554 (2006).
  43. J. Jo, M. Yamamoto, K. Matsumoto, T. Nakamura, and Y. Tabata, Liver targeting of plasmid DNA with a cationized pullulan for tumor suppression, J. Nanoscience Nanotechnology, 6(9-10), 2853-2859 (2006).
  44. I. Kanatani, T. Ikai, A. Okazaki, J. Jo, M. Yamamoto, M. Imamura, A. Kanematsu, S. Yamamoto , N. Ito, O. Ogawa, and Y. Tabata, Efficient gene transfer by pullulan-spermine occurs through both clathrin- and raft/caveolae-dependent mechanisms, J. Control. Rel., 116(1), 75-82 (2006).
  45. M. Murata, T. Akazawa, T. Sasaki, K. Ito, J. Tazaki, M. Yamamoto, Y. Tabata, and M. Arisue, Blood Permeability of a Novel Ceramic Scaffold for BMP-2, J. Biomed. Mater. Res. B Appl. Biomater., 81(2), 469-475 (2007).
  46. Y. Takahashi, M. Yamamoto, K. Yamada, O. Kawakami, and Y. Tabata, Skull bone regeneration in non-human primates by controlled release of bone morphogenetic protein-2 from a biodegradable hydrogel, Tissue Eng., 13(2), 293-300 (2007).
  47. J. Liu, M. Yamamoto, and Y. Tabata, Antitumor Activity of Fullerene Modified by Polyethylene Glycol with Different Molecular Weights and Terminal Structures, J. Drug Targeting submitted.
  48. J. Liu, S. Ohta, A. Sonoda, M. Yamada, M. Yamamoto, N. Nitta, K. Murata, and Y. Tabata, Preparation of PEG-conjugated fullerene containing Gd3+ ions for photodynamic therapy, J. Control. Rel., 117(1), 104-110 (2007).
  49. J. Jo, T. Ikai, A. Okazaki, K. Nagane, M. Yamamoto, Y. Hirano, and Y. Tabata, Expression profile of plasmid DNA by spermine derivatives of pullulan with different molecular weights, J Biomater Sci Polym Ed., 18(7), 883-899 (2007).
  50. J. Jo, T. Ikai, A. Okazaki, K. Nagane, M. Yamamoto, Y. Hirano, and Y. Tabata, Expression profile of plasmid DNA by spermine derivatives of pullulan with different extents of spermine introduced, J. Control. Rel., 118(3), 389-398 (2007).
  51. H. Igai, Y. Yamamoto, S.S. Chang, M. Yamamoto, Y. Tabata, H. Yokomise, Tracheal cartilage regeneration by slow release of basic fibroblast growth factor from a gelatin sponge, J. Thorac. Cardiovasc. Surg., 134(1), 170-175 (2007).
  52. A. Marui, Y. Tabata, S. Kojima, M. Yamamoto, K. Tambara, T. Nishina, Y. Saji, K. Inui, T. Hashida, S. Yokoyama, R. Onodera, T. Ikeda, M. Fukushima, M. Komeda, A novel approach to therapeutic angiogenesis for patients with critical limb ischemia by sustained release of basic fibroblast growth factor using biodegradable gelatin hydrogel: an initial report of the phase I-IIa study, Circ J., 71(8), 1181-1186 (2007).
  53. T. Ishimoto, T. Nakano, Y. Umakoshi, M. Yamamoto, Y. Tabata, Change in Material and Structural Parameters of Bone Mechanical Function during Long-Bone Regeneration, Materials Science Forum, 561-565, 1451-1454? (2007).
  54. J. Tazaki, T. Akazawa, M. Murata, M. Yamamoto, Y. Tabata, J. Hino, M. Arisue, T. Shibata, Comparison of Hap and b-TCP in BMP-2 Dose-response and Release Study, Key Engineering Materials, 361-363, 1033-1036 (2008).
  55. Z. S. Patel, H. Ueda, M. Yamamoto, Y. Tabata, A. G. Mikos, In vitro and in vivo release of vascular endothelial growth factor from gelatin microparticles and biodegradable composite scaffolds, Pharm Res., 25(10), 2370-2378 (2008).
  56. Z. S. Patel, M. Yamamoto, H. Ueda, Y. Tabata, A. G. Mikos, Biodegradable gelatin microparticles as delivery systems for the controlled release of bone morphogenetic protein-2, Acta Biomater., 4(5), 1126-1138 (2008).
  57. H. Igai, S. S. Chang, M. Gotoh, Y. Yamamoto, M. Yamamoto, Y. Tabata, H. Yokomise, Tracheal cartilage regeneration and new bone formation by slow release of bone morphogenetic protein (BMP)-2, ASAIO J., 54(1), 104-108 (2008).

 

RETURN