英語論文・総説

主な発表論文 Original Papers

  • Omatsu Y., Seike M., Sugiyama T., Kume T. and Nagasawa T.
    Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation.
    Nature 508(7497):536-540, 2014

  • Bannard O., Horton RM., Allen CD., An J., Nagasawa T. and Cyster JG.
    Germinal center centroblasts transition to a centrocyte phenotype according to a timed program and depend on the dark zone for effective selection.
    Immunity 39: 912-924, 2013.

  • Casanova-Acebes, M., Pitaval, C., Weiss, L.A., Nombela-Arrieta, C., Chevre, R., N, A.G., Kunisaki, Y., Zhang, D., van Rooijen, N., Silberstein, L.E., Weber, C., Nagasawa, T., Frenette, P.S., Castrillo, A. and Hidalgo, A.
    Rhythmic modulation of the hematopoietic niche through neutrophil clearance.
    Cell 153: 1025-1035, 2013.

  • Greenbaum, A., Hsu, Y.M., Day, R.B., Schuettpelz, L.G., Christopher, M.J., Borgerding, J.N., Nagasawa, T. and Link, D.C.
    CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance.
    Nature 495: 227-230, 2013.

  • Li, W., Kohara, H., Uchida, Y., James, J.M., Soneji, K., Cronshaw, D.G., Zou, Y.R., Nagasawa, T. and Mukouyama, Y.S.
    Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin.
    Dev. Cell 24: 359-371, 2013.

  • Devi S., Wang Y., Chew WK., Lima R., A-Gonzalez N., Mattar CN., Chong SZ., Schlitzer A., Bakocevic N., Chew S., Keeble JL., Goh CC., Li JL., Evrard M., Malleret B., Larbi A., Renia L., Haniffa M., Tan SM., Chan JK., Balabanian K., Nagasawa T., Bachelerie F., Hidalgo A., Ginhoux F., Kubes P. and Ng LG.
    Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow.
    J. Exp. Med. 210: 2321-2336, 2013.

  • Kanatsu-Shinohara, M., Inoue, K., Takashima, S., Takehashi, M., Ogonuki, N., Morimoto, H., Nagasawa, T., Ogura, A. and Shinohara, T.
    Reconstitution of mouse spermatogonial stem cell niches in culture.
    Cell Stem Cell 11: 567-578, 2012.

  • Nishiyama, C., Uesaka, T., Manabe, T., Yonekura, Y., Nagasawa, T., Newgreen, D.F., Young, H.M. and Enomoto, H.
    Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system.
    Nat. Neurosci. 15: 1211-1218, 2012.

  • Kubota, Y., Takubo, K., Hirashima, M., Nagoshi, N., Kishi, K., Okuno, Y., Nakamura-Ishizu, A., Sano, K., Murakami, M., Ema, M., Omatsu, Y., Takahashi, S., Nagasawa, T., Shibuya, M., Okano, H. and Suda, T.
    Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero.
    J. Exp. Med. 208: 949-960, 2011.

  • Noda, M., Omatsu, Y., Sugiyama, T., Oishi, S., Fujii, N. and Nagasawa, T.
    CXCL12-CXCR4 chemokine signaling is essential for NK-cell development in adult mice.
    Blood 117: 451-458, 2011.

  • Lei, Y., Ripen, A.M., Ishimaru, N., Ohigashi, I., Nagasawa, T., Jeker, L.T., Bosl, M.R., Hollander, G.A., Hayashi, Y., Malefyt Rde, W., Nitta, T. and Takahama, Y.
    Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development.
    J. Exp. Med. 208: 383-394, 2011.

  • Hiratsuka, S., Duda, D.G., Huang, Y., Goel, S., Sugiyama, T., Nagasawa, T., Fukumura, D. and Jain, R.K.
    C-X-C receptor type 4 promotes metastasis by activating p38 mitogen-activated protein kinase in myeloid differentiation antigen (Gr-1)-positive cells.
    Proc. Natl. Acad. Sci. USA 108: 302-307, 2011.

  • Omatsu, Y., Sugiyama, T., Kohara, H., Kondoh, G., Fujii, N., Kohno, K. and Nagasawa, T.
    The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche.
    Immunity 33: 387-399, 2010.

  • Sanematsu, F., Hirashima, M., Laurin, M., Takii, R., Nishikimi, A., Kitajima, K., Ding, G., Noda, M., Murata, Y., Tanaka, Y., Masuko, S., Suda, T., Meno, C., Cote, J.F., Nagasawa, T. and Fukui, Y.
    DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.
    Circ. Res. 107: 1102-1105, 2010.

  • Janas, M.L., Varano, G., Gudmundsson, K., Noda, M., Nagasawa, T. and Turner, M.
    Thymic development beyond beta-selection requires phosphatidylinositol 3-kinase activation by CXCR4.
    J. Exp. Med. 207: 247-261, 2010.

  • Tanaka, D. H. Yanagida, M. Zhu, Y. Mikami, S. Nagasawa, T. Miyazaki, J. Yanagawa, Y. Obata, K. Murakami, F.
    Random walk behavior of migrating cortical interneurons in the marginal zone: time-lapse analysis in flat-mount cortex.
    J. Neurosci. 29(5): 1300-11, 2009.

  • Kohara H., Omatsu Y., Sugiyama T., Noda M., Fujii N. and Nagasawa T.
    Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling.
    Blood 110: 4153-4160, 2007.

  • Sugiyama T., Kohara H., Noda M. and Nagasawa T.
    Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches.
    Immunity 25: 977-988, 2006.

  • Foudi A., Jarrier P., Zhang Y., Wittner M., Geay J.F., Lecluse Y., Nagasawa T., Vainchenker W. and Louache F.
    Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice.
    Blood 107: 2243-2251, 2006.

  • Lieberam I., Agalliu D., Nagasawa T., Ericson J. and Jessell T.M.
    A Cxcl12-CXCR4 chemokine signaling pathway defines the initial trajectory of mammalian motor axons.
    Neuron 47: 667-679, 2005.

  • Ara T., Tokoyoda K., Okamoto R., Koni P.A. and Nagasawa T.
    The role of CXCL12 in the organ-specific process of artery formation.
    Blood 105: 3155-3161, 2005.

  • Tokoyoda K., Egawa T., Sugiyama T., Choi B.I. and Nagasawa T.
    Cellular niches controlling B lymphocyte behavior within bone marrow during development.
    Immunity 20: 707-718, 2004.

  • Stumm R.K., Zhou C., Ara T., Lazarini F., Dubois-Dalcq M., Nagasawa T., Hollt V. and Schulz S.
    CXCR4 regulates interneuron migration in the developing neocortex.
    J. Neurosci. 23: 5123-5130, 2003.

  • Ara T., Itoi M., Kawabata K., Egawa T., Tokoyoda K., Sugiyama T., Fujii N., Amagai T. and Nagasawa T.
    A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivo.
    J. Immunol. 170: 4649-4655, 2003.

  • Ara T., Nakamura Y., Egawa T., Sugiyama T., Abe K., Kishimoto T., Matsui Y. and Nagasawa T.
    Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1).
    Proc. Natl. Acad. Sci. USA 100: 5319-5323, 2003.

  • Ara T., Tokoyoda K., Sugiyama T., Egawa T., Kawabata K. and Nagasawa T.
    Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny.
    Immunity 19: 257-267, 2003.

  • Zhu Y., Yu T., Zhang X.C., Nagasawa T., Wu J.Y. and Rao Y.
    Role of the chemokine SDF-1 as the meningeal attractant for embryonic cerebellar neurons.
    Nat. Neurosci. 5: 719-720, 2002.

  • Egawa T., Kawabata K., Kawamoto H., Amada K., Okamoto R., Fujii N., Kishimoto T., Katsura Y. and Nagasawa T.
    The earliest stages of B cell development require a chemokine stromal cell-derived factor/pre-B cell growth-stimulating factor.
    Immunity 15: 323-334, 2001.

  • Kawabata K., Ujikawa M., Egawa T., Kawamoto H., Tachibana K., Iizasa H., Katsura Y., Kishimoto T. and Nagasawa T.
    A cell-autonomous requirement for CXCR4 in long-term lymphoid and myeloid reconstitution.
    Proc. Natl. Acad. Sci. USA 96: 5663-5667, 1999.

  • Tachibana K., Hirota S., Iizasa H., Yoshida H., Kawabata K., Kataoka Y., Kitamura Y., Matsushima K., Yoshida N., Nishikawa S., Kishimoto T. and Nagasawa T.
    The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.
    Nature 393: 591-594, 1998.

  • Ma Q., Jones D., Borghesani P.R., Segal R.A., Nagasawa T., Kishimoto T., Bronson R.T. and Springer T.A.
    Impaired B-lymphopoiesis, myelopoiesis and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.
    Proc. Natl. Acad. Sci. USA 95: 9448-9453, 1998.

  • Tachibana K., Nakajima T., Sato A., Igarashi K., Shida H., Iizasa H., Yoshida N., Yoshie O., Kishimoto T. and Nagasawa T.
    CXCR4/fusin is not a species-specific barrier in murine cells for HIV-1 entry.
    J. Exp. Med. 185: 1865-1870, 1997.

  • Murakami T., Nakajima T., Koyanagi Y., Tachibana K., Fujii N., Tamamura H., Yoshida N., Waki M., Matsumoto A., Yoshie O., Kishimoto T., Yamamoto N. and Nagasawa T.
    A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection.
    J. Exp. Med. 186: 1389-1393, 1997.

  • Nagasawa T., Hirota S., Tachibana K., Takakura N., Nishikawa S., Kitamura Y., Yoshida N., Kikutani H. and Kishimoto T.
    Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1.
    Nature 382: 635-638, 1996.

  • Nagasawa T., Nakajima T., Tachibana K., Iizasa H., Bleul C.C., Yoshie O., Matsushima K., Yoshida N., Springer T.A. and Kishimoto T.
    Molecular cloning and characterization of a murine pre-B-cell growth-stimulating factor/stromal cell-derived factor 1 receptor, a murine homolog of the human immunodeficiency virus 1 entry coreceptor fusin.
    Proc. Natl. Acad. Sci. USA 93: 14726-14729, 1996.

  • Nagasawa T., Kikutani H. and Kishimoto T.
    Molecular cloning and structure of a pre-B-cell growth-stimulating factor.
    Proc. Natl. Acad. Sci. USA 91: 2305-2309, 1994.

  • Nagasawa T., Kaisho T., Kishimoto T. and Kikutani H.
    Generation and characterization of a monoclonal antibody that inhibits stromal cell-dependent B lymphopoiesis.
    J. Immunol. 152: 2788-2797, 1994.

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