Publications (2010- 2013 )






Uosaki H, Magadum A, Seo K, Fukushima H, Takeuchi A, Nakagawa Y, Moyes KW, Narazaki G, Kuwahara K, Laflamme M, Matsuoka S, Nakatsuji N,Nakao K, Kwon C, Kass DA, Engel FB, Yamashita JK.

Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells.

Circ Cardiovasc Genet. 2013 Dec;6(6):624-33. doi: 10.1161/CIRCGENETICS.113.000330. Epub 2013 Oct 18.


Watatani K, Xie Z, Nakatsuji N, Sengoku S.

Global competencies of regional stem cell research: bibliometrics for investigating and forecasting research trends.

Regen Med. 2013 Sep;8(5):659-68. doi: 10.2217/rme.13.51. Epub 2013 Jul 1.

Kumagai H, Suemori H, Uesugi M, Nakatsuji N, Kawase E.
Identification of small molecules that promote human embryonic stem cell self-renewal.
Biochem Biophys Res Commun. 2013 Mar 27.


Miyazaki T, Futaki S, Suemori H, Taniguchi Y, Yamada M, Kawasaki M, Hayashi M, Kumagai H, Nakatsuji N, Sekiguchi K, Kawase E.
Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells.
Nat Commun. 2012;3:1236. doi: 10.1038/ncomms2231.


Kadota S, Minami I, Morone N, Heuser JE, Agladze K, Nakatsuji N.
Development of a reentrant arrhythmia model in human pluripotent stem cell-derived cardiac cell sheets.
Eur Heart J. 2013 Apr;34(15):1147-56. doi: 10.1093/eurheartj/ehs418. Epub 2012 Nov 30.


Wada T, Goparaju SK, Tooi N, Inoue H, Takahashi R, Nakatsuji N, Aiba K.
Amyotrophic lateral sclerosis model derived from human embryonic stem cells overexpressing mutant superoxide dismutase 1.
Stem Cells Transl Med. 2012 May;1(5):396-402. doi: 10.5966/sctm.2011-0061. Epub 2012 May 8.


Hasegawa K, Yasuda SY, Teo JL, Nguyen C, McMillan M, Hsieh CL, Suemori H, Nakatsuji N, Yamamoto M, Miyabayashi T, Lutzko C, Pera MF, Kahn M.
Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion.
Stem Cells Transl Med. 2012 Jan;1(1):18-28. doi: 10.5966/sctm.2011-0033. Epub 2011 Dec 7.


Tsuneyoshi N, Tan EK, Sadasivam A, Poobalan Y, Sumi T, Nakatsuji N, Suemori H, Dunn NR.
The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells.
Genes Dev. 2012 Nov 15;26(22):2471-6. doi: 10.1101/gad.201772.112.


Minami I, Yamada K, Otsuji TG, Yamamoto T, Shen Y, Otsuka S, Kadota S, Morone N, Barve M, Asai Y, Tenkova-Heuser T, Heuser JE, Uesugi M, Aiba K, Nakatsuji N.
A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions.
Cell Rep. 2012 Nov 29;2(5):1448-60. doi: 10.1016/j.celrep.2012.09.015. Epub 2012 Oct 25.


Jung D, Abu-Elheiga L, Ayuzawa R, Gu Z, Shirakawa T, Fujiki Y, Nakatsuji N, Wakil SJ, Uesugi M.
Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule.
Biochem J. 2012 Dec 15;448(3):409-16. doi: 10.1042/BJ20121158.


Otsuji TG, Kurose Y, Suemori H, Tada M, Nakatsuji N.
Dynamic link between histone H3 acetylation and an increase in the functional characteristics of human ESC/iPSC-derived cardiomyocytes.
PLoS One. 2012;7(9):e45010. doi: 10.1371/journal.pone.0045010. Epub 2012 Sep 12.


Liu L, Yuan Q, Shi J, Li X, Jung D, Wang L, Yamauchi K, Nakatsuji N, Kamei K, Chen Y.
Chemically-defined scaffolds created with electrospun synthetic nanofibers to maintain mouse embryonic stem cell culture under feeder-free conditions.
Biotechnol Lett. 2012 Oct;34(10):1951-7. doi: 10.1007/s10529-012-0973-9. Epub 2012 Jun 20.


Jung D, Minami I, Patel S, Lee J, Jiang B, Yuan Q, Li L, Kobayashi S, Chen Y, Lee KB, Nakatsuji N.
Incorporation of functionalized gold nanoparticles into nanofibers for enhanced attachment and differentiation of mammalian cells.
J Nanobiotechnology. 2012 Jun 11;10:23. doi: 10.1186/1477-3155-10-23.


Iijima Y, Kornhauser DH, Nakatsuji N.
Heidelberg-Kyoto partnership bridges life and materials sciences, strengthens bilateral ties.
Biotechnol J. 2012 Jun;7(6):699-700. doi: 10.1002/biot.201200166.


Ho A, Nakatsuji N.
Editorial: "crossing boundaries: stem cells, materials, and mesoscopic sciences".
Biotechnol J. 2012 Jun;7(6):694-5. doi: 10.1002/biot.201200156.


Kamimura R, Ishii T, Sasaki N, Kajiwara M, Machimoto T, Saito M, Kohno K, Suemori H, Nakatsuji N, Ikai I, Yasuchika K, Uemoto S.
Comparative study of transplantation of hepatocytes at various differentiation stages into mice with lethal liver damage.
Cell Transplant. 2012;21(11):2351-62. doi: 10.3727/096368912X636957. Epub 2012 Apr 2.


Aizawa E, Hirabayashi Y, Iwanaga Y, Suzuki K, Sakurai K, Shimoji M, Aiba K, Wada T, Tooi N, Kawase E, Suemori H, Nakatsuji N, Mitani K.
Efficient and accurate homologous recombination in hESCs and hiPSCs using helper-dependent adenoviral vectors.
Mol Ther. 2012 Feb;20(2):424-31. doi: 10.1038/mt.2011.266. Epub 2011 Dec 6.


International Stem Cell Initiative, Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y, Ward-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q.
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.
Nat Biotechnol. 2011 Nov 27;29(12):1132-44. doi: 10.1038/nbt.2051.


Uosaki H, Fukushima H, Takeuchi A, Matsuoka S, Nakatsuji N, Yamanaka S, Yamashita JK.
Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression.
PLoS One. 2011;6(8):e23657. doi: 10.1371/journal.pone.0023657. Epub 2011 Aug 18.

Tanaka T, Hosokawa M, Vagin VV, Reuter M, Hayashi E, Mochizuki AL, Kitamura K, Yamanaka H, Kondoh G, Okawa K, Kuramochi-Miyagawa S, Nakano T, Sachidanandam R, Hannon GJ, Pillai RS, Nakatsuji N, Chuma S.
Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.
Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10579-84.



Sasaki N, Ishii T, Kamimura R, Kajiwara M, Machimoto T, Nakatsuji N, Suemori H, Ikai I, Yasuchika K, Uemoto S.
Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics.
Cancer Lett. 2011 Sep 28;308(2):152-61.



Nagae G, Isagawa T, Shiraki N, Fujita T, Yamamoto S, Tsutsumi S, Nonaka A, Yoshiba S, Matsusaka K, Midorikawa Y, Ishikawa S, Soejima H, Fukayama M, Suemori H, Nakatsuji N, Kume S, Aburatani H.

Tissue-specific demethylation in CpG-poor promoters during cellular differentiation.
Hum Mol Genet. 2011 Jul 15;20(14):2710-21.

 

 

Watanabe T, Chuma S, Yamamoto Y, Kuramochi-Miyagawa S, Totoki Y, Toyoda A, Hoki Y, Fujiyama A, Shibata T, Sado T, Noce T, Nakano T, Nakatsuji N, Lin H, Sasaki H.

MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.
Dev Cell. 2011 Mar 15;20(3):364-75.

 

 

Fujiwara M, Yan P, Otsuji TG, Narazaki G, Uosaki H, Fukushima H, Kuwahara K, Harada M, Matsuda H, Matsuoka S, Okita K, Takahashi K, Nakagawa M, Ikeda T, Sakata R, Mummery CL, Nakatsuji N, Yamanaka S, Nakao K, Yamashita JK.

Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A.
PLoS One. 2011 Feb 22;6(2):e16734.

 


Murakami, G., Inoue, H., Tsukita, K., Asai, Y., Amagai, Y., Aiba, K., Shimogawa, H., Uesugi, M., Nakatsuji, N. and Takahashi, R.

Chemical library screening identifies a small molecule that 1 downregulates SOD1 transcription for drugs to treat ALS.
 J. Biomolecular Screening, in press (2010)

 

 

Tatsumi R, Suzuki Y, Sumi T, Sone M, Suemori H, Nakatsuji N.

Simple and highly efficient method for production of endothelial cells from human embryonic stem cells.
Cell Transplant. 2010 Dec 22. [Epub ahead of print]

 


Sengoku S, Sumikura K, Oki T, Nakatsuji N.

Redefining the Concept of Standardization for Pluripotent Stem Cells.
Stem Cell Rev. 2011 Nov 18. Jun;7(2):221-6.

 


Yamauchi K, Sumi T, Minami I, Otsuji TG, Kawase E, Nakatsuji N, Suemori H.

Cardiomyocytes develop from anterior primitive streak cells induced by β-catenin activation and the blockage of BMP signaling in hESCs.
Genes Cells. 2010 Dec;15(12):1216-27.

 


Nakatsuji N.

Banking human pluripotent stem cell lines for clinical application?
J Dent Res. 2010 Aug;89(8):757-8. Epub 2010 Jun 16. No abstract available.

 


Kuramochi-Miyagawa S, Watanabe T, Gotoh K, Takamatsu K, Chuma S, Kojima-Kita K, Shiromoto Y, Asada N, Toyoda A, Fujiyama A, Totoki Y, Shibata T, Kimura T, Nakatsuji N, Noce T, Sasaki H, Nakano T.

MVH in piRNA processing and gene silencing of retrotransposons.
Genes Dev. 2010 May;24(9):887-92.

 

 

Adachi K, Suemori H, Yasuda SY, Nakatsuji N, Kawase E.

Role of SOX2 in maintaining pluripotency of human embryonic stem cells.
Genes Cells. 2010 May; 15(5) 455-70

 

Asai Y, Tada M, Otsuji TG, Nakatsuji N.

Combination of Functional Cardiomyocytes Derived from Human Stem Cells and a Highly-Efficient Microelectrode Array System: An Ideal Hybrid Model Assay for Drug Development.
Curr Stem Cell Res Ther. 2010 Sep; 5(3) 227-32

 

Otsuji TG, Minami I, Kurose Y, Yamauchi K, Tada M, Nakatsuji N.

Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs.
Stem Cell Res. 2010 May; 4(3) 201-13

 

International Stem Cell Initiative Consortium, Akopian V, Andrews PW, Beil S, Benvenisty N, Brehm J, Christie M, Ford A, Fox V, Gokhale PJ, Healy L, Holm F, Hovatta O, Knowles BB, Ludwig TE, McKay RD, Miyazaki T,
Nakatsuji N, Oh SK, Pera MF, Rossant J, Stacey GN, Suemori H.

Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells.
In Vitro Cell Dev Biol Anim. 2010 Apr;46(3-4):247-58.

 

Liu L, Luo C, Ni X, Wang L, Yamauchi K, Nomura SM, Nakatsuji N, Chen Y.

A micro-channel-well system for culture and differentiation of embryonic stem cells on different types of substrate.
Biomed Microdevices. 2010 Jun; 12(3) 505-11

 

Kumagai Y, Kurokawa MS, Ueno H, Kayama M, Tsubota K, Nakatsuji N, Kondo Y, Ueno S, Suzuki N.
 
Induction of Corneal Epithelium-Like Cells From Cynomolgus Monkey Embryonic Stem Cells and Their Experimental Transplantation to Damaged Cornea.
Cornea. 2010 Apr; 29(4) 432-8

 

Ishii T, Yasuchika K, Suemori H, Nakatsuji N, Ikai I, Uemoto S.

Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma.
Cancer Lett. 2010 Aug 1; 294(1) 25-34

 


Sakurai K, Shimoji M, Tahimic CG, Aiba K, Kawase E, Hasegawa K, Amagai Y, Suemori H, Nakatsuji N.

Efficient integration of transgenes into a defined locus in human embryonic stem cells.
Nucleic Acids Res. 2010 Apr 1;38(7):e96.

 

Shoji M, Tanaka T, Hosokawa M, Reuter M, Stark A, Kato Y, Kondoh G, Okawa K, Chujo T, Suzuki T, Hata K, Martin SL, Noce T, Kuramochi-Miyagawa S, Nakano T, Sasaki H, Pillai RS, Nakatsuji N, Chuma S.

The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.
Dev Cell. 2009 Dec;17(6):775-87.

 

Ishii T, Yasuchika K, Fukumitsu K, Kawamoto T, Kawamura-Saitoh M, Amagai Y, Ikai I, Uemoto S, Kawase E, Suemori H, Nakatsuji N.

In vitro hepatic maturation of human embryonic stem cells by using a mesenchymal cell line derived from murine fetal livers.
Cell Tissue Res. 2010 Mar;339(3):505-12.

 

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