P u b l i c a t i o n (A r t i c l e)

          

       Teshigawara,R., Cho,J.K., Kameda,M. and Tada,T. (2017)
       Mechanism of Human Somatic Reprogramming to iPS Cell.
       Laboratory Investigation, doi: 10.1038/labinvest.2017.56. .

       Teshigawara, R., Hirano, K., Nagata, S., Ainscough, J. and Tada, T. (2016)
       OCT4 activity during conversion of human intermediately reprogrammed stem cells to iPSCs through mesenchymal-epithelial transition.
       Development, 143,15-23.

       Vincent Pasque, Jason Tchieu, Rahul Karnik, Molly Uyeda, Anupama Sadhu Dimashkie, Dana Case, Bernadett Papp, Giancarlo Bonora,
       Sanjeet Patel, Ritchie Ho, Ryan Schmidt, Robin McKee, Takashi Sado, Takashi Tada, Alexander Meissner, and Kathrin Plath. (2014)
       X Chromosome Reactivation Dynamics Reveal Stages of Reprogramming to Pluripotency.
       Cell, 159,1681-1697.

       Matsumura, T., Tatsumi, K., Noda,Y., Nakanishi,N., Okonogi,A., Hirano,K., Li Liu, Osumi,T., Tada,T. and Kotera,H. (2014)
       Single-cell cloning and expansion of human induced pluripotent stem cells by a microfluidic culture device.
       Biochemical and Biophysical Research Communications, 453,131-137.

       Sun, L.T., Yamaguchi,S., Hirano,K., Ichisaka,T., Kuroda,T. and Tada,T. (2014)
       Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast.
       Developmental Biology, 15 ; 392(2) :182-192.

       Terao, K., Gel, M., Okonogi, A., Fuke, A., Okitsu, T., Tada,T., Suzuki, T., Nagamatsu,S., Washizu, M. and Kotera, H. (2014)
       Subcellular glucose exposure biases the spatial distribution of insulin granules in single pancreatic beta cells.
       Scientific Reports, 4 : 4123.

       Piccolo, F. M., Bagci, H., Brown, K. E., Landeira, D., Soza-Ried, J., Feytout, A., Mooijman, D., Hajkova, P., Leitch, H. G.,
       Tada, T., Kriaucionis, S., Dawlaty, M. M., Jaenisch, R., Merkenschlager, M. and Fisher, A. G. (2013)
       Different Roles for Tet1 and Tet2 Proteins in Reprogramming-Mediated Erasure of Imprints Induced by EGC Fusion.
       Molecular Cell, 49,1023-1033.

       Nagata, S., Hirano, K., Sun, L.T. and Tada, T. (2012)
       Self-renewal and pluripotency acquired through somatic reprogramming to human cancer stem cells.
       PLoS ONE, 7, e48699.

       Okamura, D., Mochizuki, K., Taniguchi, H., Tokitake, Y., Ikeda, M., Yamada, Y., Tournier, C., Yamaguchi, S., Tada, T.,
       Scholer, H.R. and Matsui, Y. (2012)
       REST and its downstream molecule Mek5 regulate survival of primordial germ cells.
       Developmental Biology, 372,190-202.

       Takehashi, M., Tada, M., Kanatsu-Shinohara, M., Morimoto, H., Kazuki, Y., Oshimura, M., Tada, T. and Shinohara, T. (2012)
       Hybridization of testis-derived stem cells with somatic and embryonic stem cells.
       Biology of Reproduction, 86, e178,1-9.

       Cheng, L.T., Sun, L.T. and Tada, T. (2012)
       Genome editing in induced pluripotent stem cells.
       Genes to Cells,17,431-438.

       Hirano, K., Nagata, S., Yamaguchi, S., Nakagawa, M., Okita, K., Kotera, H., Ainscough, J. and Tada, T. (2012)
       Human and mouse induced pluripotent stem cells are differentially reprogrammed in response to kinase inhibitors.
       Stem Cells and Development,21,1287-1298.

       Cheng, L.T., Nagata,S., Hirano,K., Yamaguchi,S., Horie,S., Ainscough,J. and Tada,T. (2012)
       Cure of ADPKD by selection for spontaneous genetic repair events in Pkd1-mutated iPS cells.
       PLoS ONE, 7, e32018.

       Yamaguchi, S., Hirano, K., Nagata, S. and Tada, T. (2011)
       Sox2 expression effects on direct reprogramming efficiency as determined by alternative somatic cell fate.
       Stem Cell Res., 6,177-186.

       Shineha, R., Kawakami, M., Kawakami, K., Nagata, M., Tada, T. and Kato, K.(2010)
       Familiarity and prudence of the Japanese public with research into induced pluripotent stem cells, and their desire for its proper regulation.
       Stem Cell Rev., 6, 1-7.

       Yamaguchi,S., Kurimoto,K.,Yabuta,Y., Sasaki,H., Nakatsuji,N., Saitou,M. and Tada,T. (2009)
       Conditional knockdown of Nanog induces apoptotic cell death in mouse migrating primordial germ cells.
       Development, 136, 4011-4020.

       Nagata,S., Toyoda,M., Yamaguchi,S., Hirano,K., Makino,H., Nishino,K., Miyagawa,Y., Okita,H., Kiyokawa,N., Nakagawa,M.,
       Yamanaka,S., Akutsu,H., Umezawa,A. and Tada,T. (2009)
       Efficient Reprogramming of Human and Mouse Primary Extra-Embryonic Cells to Pluripotent Stem Cells.
       Genes Cells, 14,1395-1404.

       Tada, M., Matsumura, H., Kurose, Y., Nakatsuji, N. and Tada, T. (2009)
       Target chromosomes of inducible deletion by a Cre/inverted loxP system in mouse embryonic stem cells.
       Chromosome Research, 17, 443-450.

       Mise, N., Fuchikami, T., Sugimoto, M., Kobayakawa, S., Ike, F., Ogawa, T., Tada, T., Kanaya, S., Noce, T. and Abe, K. (2008)
       Differences and similarities in the developmental status of embryo-derived stem cells and primordial germ cells revealed
       by global expression profiling.
       Genes Cells, 13, 863-877.

       Tada, T. (2008)
       Genetic modification-free reprogramming to induced pluripotent cells: fantasy or reality?
       Cell Stem Cell, 3, 121-122.

       Otsuji, T., Matsumura, H., Suzuki, T., Nakatsuji, N., Tada, T. and Tada, M. (2008)
       Rapid induction of large chromosomal deletions by a Cre/inverted loxP system in mouse ES Cell hybrids.
       J Mol Biol, 378,328-336.

       Matsumura, H. and Tada, T. (2008)
       Cell fusion-mediated nuclear reprogramming of somatic cells.
       Reprod Biomed Online, 16,51-56.

       Matsumura,H., Tada,M., Otsuji,T., Yasuchika, K., Nakatsuji,N., Surani, A. and Tada,T. (2007)
       Targeted chromosome elimination from ES-somatic hybrid cells.
       Nature Methods, 4,23-25.

       Yasuda,S., Tsuneyoshi,N., Sumi.T., Hasegawa,K., Tada,T., Nakatsuji,N. and Suemori,H.(2006)
       NANOG maintains self-renewal of primate ES cells in the absence of feeder layer.
       Genes Cells, 11,1115-1123.

       Popova.B.C., Tada,T., Takagi,N., Brickdorff,N. and Nesterova,T.B. (2006)
       Attenuated spread of X-inactivation in an X;autosome translocation.
       Proc. Natl. Acad. Sci. USA, 103, 7706-7711.

       Tada,T. (2006)
       Toti-/pluripotential stem cells and epigenetic modifications.
       Neuro-degenerative Diseases, 3,32-37.

       Hasegawa,K.,Chuma,S., Tada,T., Sakurai,T., Tamura,M., Suemori,H. and Nakatsuji,N. (2006)
       Testatin transgenic and knockout mice exhibit normal sex-differentiation.
       Biochem. Biophys. Res. Commun., 341,369-375.

       Yamaguchi,S., Kimura,H., Tada,M., Nakatsuji,N. and Tada,T. (2005)
       Nanog expression in mouse germ cell development.
       MOD Gene Expr. Patterns, 5, 639-646.

       Kuroda, T., Tada, M., Kubota, H., Kimura, H., Hatano,S., Suemori,H., Nakatsuji,N. and Tada,T.(2005)
       Octamer and Sox elements are required for transcriptional cis regulation of Nanog gene expression.
       Mol. Cell. Biol., 25, 2475-2485.

       Hatano, S., Tada, M., Kimura, H., Yamaguchi, S., Kono, T., Suemori, H., Nakatsuji, N. and Tada, T. (2005)
       Pluripotential competence of cells associated with Nanog activity.
       Mech. Dev., 122, 67-79.

       Ohhata, T., Tachibana, M., Tada, M., Tada, T., Sasaki, H., Shinkai, Y. and Sado, T. (2004)
       X-inactivation is stably maintained in mouse embryos deficient for Histone methyltransferase G9a.
       Genesis, 40, 151-156.

       Kimura, H., Tada, M., Nakatsuji, N. and Tada, T. (2004)
       Histone code modifications on pluripotential nuclei of reprogrammed somatic cells.
       Mol. Cell. Biol., 24, 5710-5720.

       Tada, T., Kimura, H. and Tada, M. (2004)
       ”Epigenetic reprogramming ”and” Nuclear reprogramming”.
       Journal of Mammalian Ova Research (Review), 21,97-104.

       Tada, M., Morizane, A., Kimura, H., Kawasaki, H., Ainscough, J. F. X., Sasai, Y., Nakatsuji, N. and Tada, T. (2003)
       Pluripotency of reprogrammed somatic genomes in ES hybrid cells.
       Dev. Dyn., 227, 504-510.

       Kimura, H., Tada, M., Hatano, S., Yamazaki, M., Nakatsuji, N. and Tada, T. (2002)
       Chromatin reprogramming of male somatic cell- derived Xist and Tsix in ES hybrid cells.
       Cytogenet. Genome. Res., 99, 106-114.

       Watanabe, D., Suetake, I., Tada, T. and Tajima, S. (2002)
       Stage- and cell- specific expression of Dnmt3a and Dnmt3b during embryogenesis .
       Mech. Dev., 118, 187- 190.

       Tada, M., Takahama, Y., Abe, K., Nakatsuji, N. and Tada, T. (2001)
       Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells.
       Curr. Biol., 11, 1553- 1558.

       Tada, T. and Tada, M. (2001)
       Toti-/pluri-potential stem cells and epigenetic modifications.
       Cell Struct Funct, 26, 149- 60.

       Torii, R., Hosoi, Y., Fujinami, N., Tada, T., Suemori, H. et al. (2001)
       Establishment of the primate embryonic stem cell lines from blastcysts produced by intracytoplasmic sperm injection (ICSI)
       or invitro fertilization (IVF) using the Japanese monkey and the Cynomolgus monkey.
       Theriogenology, 55, 374.

       Suemori, H., Tada, T., Torii, R., Hosoi, Y., Kobayashi, K., Imahie, H., Kondo, Y., Iritani, A. and Nakatsuji, N. (2001)
       Establishment of embryonic stem cell lines from cynomolgus monkey blastocysts produced by IVF or ICSI.
       Dev. Dyn., 222, 273- 279.

       Tada, T., Obata, Y., Tada, M., Goto, Y., Nakatsuji, N., Tan, S., Kono, T. and Takagi, N. (2000)
       Imprint switching for non-random X-chromosome inactivation during mouse oocyte growth.
       Development, 127, 3101-3105.

       Park, J-I., Yoshida, I., Tada, T., Takagi, N., Takahashi, Y. and Kanagawa, H.(1998)
       Trisomy 8 does not affect differentiative potential in a murine parthenogenetic embryonic stem cell line.
       Jpn. J. Vet. Res., 46, 29-35.

       Park, J-I., Yoshida, I., Tada, T., Takagi, N., Takahashi, Y. and Kanagawa, H. (1998)
       Differentiative potential of a mouse parthenogenetic embryonic stem cell line revealed by embryoid body formation in vitro.
       Jpn. J. Vet. Res., 46, 19-28.

       Tada, T., Tada, M., Hilton, K., Barton, S. C., Sado, T., Takagi, N. and Surani, M. A. (1998)
       Epigenotype switching of imprintable loci in embryonic germ cells.
       Dev. Gene Evol., 207, 551-561.

       Tada, M., Tada, T., Lefebvre, L., Barton, S. C. and Surani, M. A. (1997)
       Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells.
       EMBO J., 16, 6510-6520.

       Ainscough, J. F.-X., Koide, T., Tada, M., Barton, S. and Surani, M. A. (1997)
       Imprinting of Igf2 and H19 from a 130 kb YAC transgene.
       Development, 124, 3621- 3632.

       Kikyo, N., Tada, M., Tada, T. and Surani, M. A. (1997)
       Mapping of the eukaryotic initiation factor eIF-1A gene, Eif1a, to mouse chromosome 12D-E by FISH.
       Mammalian Genome, 8, 376.

       Kikyo, N., Rideout, W. M. III, Tada, T., Tada, M. and Surani, M. A. (1997)
       Mapping of the Fas-associated factor 1 gene, Faf1, to mouse chromosome 4C6 by FISH.
       Mammalian Genome, 8, 224-225.

       Mise, N., Sado, T., Tada, M., Takada, S. and Takagi, N. (1996)
       Activation of the inactive X chromosome induced by cell fusion between a murine EC and female somatic cell
       accompanies reproducible changes in the methylation pattern of the Xist gene.
       Exp. Cell Res., 223, 193-202.

       Kuroiwa, Y., Ishino-Kaneko, T., Kagitani, F., Kohda, T., Li, L.-L., Tada, M., Suzuki, R., Yokoyama, M., Shiroishi, T.,
       Wakana, S., Barton, S. C., Ishino, F. and Surani, M. A. (1996)
       Peg3 imprinted gene on proximal chromosome 7 encodes for a zinc finger protein.
       Nat. Genet., 12, 186-190.

       Tada, M., Tada, T., Takagi, N., Hayashizaki, Y., Shibata, H., Hirotsune, S., Okazaki, Y., Muramatsu, M., Sasaki, H.,
       Ueda, T. and Chapman, V. M. (1994)
       Localization of mouse imprinted gene U2af1-rs1 to A3.2-4 band of chromosome 11 by FISH.
       Mammalian Genome, 5, 655.

       Tada, T., Tada, M. and Takagi, N. (1993)
       X chromosome retains the memory of the parental origin in murine embryonic stem cells.
       Development, 119, 813-821.

       Tada, T., Takagi, N. and I-D. Adler. (1993)
       Parental imprinting on the mouse X chromosome: effects on the early development of X0, XXY and XXX embryos.
       Genet. Res., 62, 139-148.

       Tada, T. and Takagi, N. (1992)
       Missing polar trophectoderm cell lineage in murine parthenogenones at early postimplantation stages.
       Mol. Rep. Dev., 31, 20-27.