業績 …論文リスト…

2013 (*corresponding author)
  1. Uosaki H*, Magadum A, Seo K, Fukushima H, Takeuchi A, Nakagawa Y, Moyes KW, Narazaki G, Kuwahara K, Laflamme M, Matsuoka S, Nakatsuji N, Nakao K, Kwon C, Kass DA, Engel FB, Yamashita JK*. Identification of chemicals inducing cardiomyocyte proliferation in developmental stage-specific manner with pluripotent stem cells. Circ Cardiovasc Genet, 6:624-633, 2013. doi: 10.1161/CIRCGENETICS.113.000330

  2. Yamamizu K, Furuta S, Hamada Y, Yamashita A, Kuzumaki N, Narita M, Doi K, Katayama S, Nagase H, Yamshita JK, Narita M. k Opioids inhibit tumor angiogenesis by suppressing VEGF signaling. Sci Rep, 3:3213, 2013. doi: 10.1038/srep03213.

  3. Kito T, Shibata R, Ishii M, Suzuki H, Himeno T, Kataoka Y, Yamamura Y, Yamamoto T, Nishio N, Ito S, Numaguchi Y, Tanigawa T, Yamshita JK, Ouchi N, Honda H, Isobe K, Murohara T. iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis. Sci Rep, 3:1418, 2013.

  4. Masumoto H, Yamashita JK. Pluripotent stem cells for cardiac cell therapy: The application of cell sheet technology. In Deepa Bhartiya and Nibedita Lenka. Pluripotent Stem Cells., Chaper 21, p459-p475. InTech, 2013 (Review).

  5. Masumoto H, Yamashita JK*.Strategies in cell therapy for cardiac regeneration. Inflammation and Regeneration, 33: 114-120, 2013 (Review)

2012
  1. Yamamizu K, Fujihara M, Tachibana M, Katayama S, Takahashi A, Hara E, Imai H, Shinkai Y, Yamshita JK*. Protein kinase A determines timing of early differentiation through epigenetic regulation with G9a. Cell Stem Cell, 10: 759-770, 2012

  2. Masumoto H, Matsuo T, Yamamizu K, Uosaki H, Narazaki G, Katayama S, Marui A, Shimizu T, Ikeda T, Okano T, Sakata R, Yamshita JK*. Pluripotent stem cell-engineered cell sheets re-assembled with defined cardiovascular populations ameliorate reduction in infarct heart function with cardiomyocyte-mediated neovascularization. Stem Cells, 30: 1196–1205, 2012

  3. Yamamizu K, Matsunaga T, Katayama S, Kataoka H, Takayama N, Eto K, Nishikawa SI, Yamshita JK*. PKA/CREB signaling triggers initiation of endothelial and hematopoietic cell differentiation via Etv2 induction. Stem Cells, 30: 687-696, 2012

  4. Kuzumaki N, Suzuki A, Narita M, Hosoya T, Nagasawa A, Imai S, Yamamizu K, Morita H, Nagase H, Okada Y, Okano HJ, Yamshita JK, Okano H, Suzuki T, Narita M. Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells. Br J Cancer, 106: 1148-1152, 2012

2011
  1. Uosaki H, Fukushima H, Takeuchi A, Matsuoka S, Nakatsuji N, Yamanaka S, Yamshita JK*. Efficient and scalable purification of cardiomyocytes from human embryonic and induced pluripotent stem cells by VCAM1 surface expression. PLoS One, e23657. 2011

  2. Yamamizu K, Furuta S, Katayama S, Narita M, Kuzumaki N, Imai S, Nagase H, Suzuki T, Narita M*, Yamshita JK*. The kappa opioid system regulates endothelial cell differentiation and pathfinding in vascular development. Blood, 118: 775-785, 2011 [Cover image]

  3. Fujiwara M, Yan P, Otsuji TG, Narazaki G, Uosaki H, Fukushima H, Kuwahara K, Harada M, Matsuda H, Matsuoka S, Okita K, Takahashi K, Nakagawa M, Ikeda T, Sakata R, Mummery CL, Nakatsuji N, Yamanaka S, Nakao K, Yamshita JK*. Induction and enhancement of cardiac cell differentiation from mouse and human induced pluripotent stem cells with cyclosporin-A. PLoS One, 6: e16734, 2011

  4. Uosaki H, Yamashita JK*. Chemicals Regulating Cardiomyocyte Differentiation. In Craig Atwood. Embryonic Stem Cells: The Hormonal Regulation of Pluripotency and Embryogenesis. Chaper 24, p471-p486. InTech, 2011 (Review).

  5. Yamamizu K, Yamashita JK*. Roles of cyclic adenosine monophosphate signaling in endothelial cell differentiation and arterial-venous specification during vascular development. Circ J, 75: 253-260 2011 (Review)

2010
  1. Yamashita JK* ES and iPS cell research for cardiovascular regeneration. Exp Cell Res, 316:2555-2559,2010 (Review)

  2. Yamamizu K, Matsunaga T, Uosaki H, Fukushima H, Katayama S, Hiraoka-Kanie M, Mitani K, Yamshita JK*. Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors. J Cell Biol, 189: 325-338, 2010

  3. Suzuki H, Shibata R, Kito T, Ishii M, Li P, Yoshikai T, Nishio N, Ito S, Numaguchi Y, Yamshita JK, Murohara T, Isobe K. Therapeutic angiogenesis by transplantation of induced pluripotent stem cell-derived Flk-1 positive cells. BMC Cell Biol, 11: 72, 2010

  4. Matsuda M, Yamshita JK, Tsukita S, Furuse M. abLIM3 is a novel component of adherens junctions with actin-binding activity. Eur J Cell Biol, 89: 807-816, 2010

2009
  1. Yamamizu K, Kawasaki K, Katayama S, Watabe T, Yamshita JK* Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and Neuropilin-1. Blood, 114: 3707-3716, 2009 pubmed

  2. Narazaki G, Yamashita JK* Creations of biological Pacemaker. Inflammation and Regeneration, 29: 123-127, 2009 (Review).

  3. Kuratomi S, Ohmori Y, Ito M, Shimazaki K, Muramatsu SI, Mizukami H, Uosaki H, Yamshita JK, Arai Y, Kuwahara K, Takano M. The cardiac pacemaker-specific channel Hcn4 is a direct transcriptional target of MEF2. Cardiovasc Res, 83: 682-687, 2009

  4. Sasaki D, Shimizu T, Masuda S, Kobayashi J, Itoga K, Tsuda Y, Yamshita JK, Yamato M, Okano T. Mass preparation of size-controlled mouse embryonic stem cell aggregates and induction of cardiac differentiation by cell patterning method. Biomaterials, 30: 4384-4389, 2009.

  5. Yan P, Nagasawa A, Uosaki H, Sugimoto A, Yamamizu K, Teranishi M, Matsuda H, Matsuoka S, Ikeda T, Komeda M, Sakata R, Yamshita JK*. Cyclosporin-A potently induces highly cardiogenic progenitors from embryonic stem cells. Biochem Biophys Res Commun, 379: 115-120, 2009

2008
  1. Narazaki G, Uosaki M, Teranishi M, Okita K, Kim B, Matsuoka S, Yamanaka S, Yamshita JK*. Directed and systematic differentiation of cardiovascular cells from mouse induced pluripotent stem cells. Circulation, 118: 498-506, 2008 [Circulation 2008, Best Paper Award in Basic Science]

  2. Yamashita JK* A likage in the developmental pathway of vascular and hematopoietic cells. In Tanaka K, Davie EW. Recent Advances in Thrombosis and Hemostasis 2008. Part 5, p363-p373. Springer, Tokyo, 2008 (Review).

  3. Nakao Y*, Narazaki G, Hoshino T, Maeda S, Yoshida M, Maejima H, Yamshita JK*. Evaluation of antiangiogenic activity of azumamides by the in vitro vascular organization model using mouse induced pluripotent stem (iPS) cells. Bioorg Med Chem Lett, 18: 2982-2984, 2008

  4. Yamahara K, Sone M, Itoh H, Yamshita JK, Yurugi-Kobayashi T, Homma K, Chao TH, Miyashita K, Park K, Oyamada N, Sawada N, Taura D, Tamura N, Nakao K. Augmentation of neovascularizaiton in hindlimb ischemia by combined transplantation of human embryonic stem cells-derived endothelial and mural cells. PLoS One, 3: e1666, 2008.

  5. Matsuda M, Kobayashi Y, Masuda S, Adachi M, Watanabe T, Yamshita JK, Nishi E, Tsukita S, Furuse M. Identification of adherens junction-associated GTPase activating proteins by the fluorescence localization-based expression cloning. Exp Cell Res, 314:939-49, 2008.

  6. Shimizu N, Yamamoto K, Obi S, Kumagaya S, Masumura T, Shimano Y, Naruse K, Yamshita JK, Igarashi T, Ando J. Cyclic strain induces mouse embryonic stem cell differentiation into vascular smooth muscle cells by activating PDGF receptor {beta}. J Appl Physiol , 104: 766-772, 2008

2007
  1. Yanagi K, Takano M, Narazaki G, Uosaki H, Hoshino T, Ishii T, Misaki T, Yamashita JK*. Hyperpolarization-activated cyclic nucleotide-gated channels and T-type calcium channels confer automaticity of embryonic stem cell-derived cardiomyocytes. Stem Cells, 25: 2712-2719, 2007.

  2. Sone M, Itoh h, Yamahara K, Yamashita JK, Yurugi-Kobayashi T, Nonoguchi A, Suzuki Y, Chao TH, Sawada N, Fukunaga Y, Miyashita K, Park K, Oyamada N, Sawada N, Taura D, Tamura N, Kondo Y, Nito S, Suemori H, Nakatsuji N, Nishikawa SI, Nakao K. Pathway for differentiation of human embryonic stem cells to vascular cell components and their potential for vascular regeneration. Arterioscler Thromb Vasc Biol, 27: 2127-2134, 2007.

  3. Yamashita JK* Differentiation of arterial, venous, and lymphatic endothelial cells from vascular progenitors. Trends Cardiovasc Med, 17: 59-63, 2007 (Review).

  4. Kamo N, Yasuchika K, Fujii H, Hoppo T, Machimoto T, Ishii T, Fujita N, Tsuruo T, Yamashita JK, Kubo H, Ikai I. Two populations of Thy1-positive mesenchymal cells regulate the in vitro maturation of hepatic progenitor cells. Am J Physiol Gastrointest Liver Physiol, 292: G526-534, 2007.

2006
  1. Hiraoka-Kanie M, Miyagishi M, Yamashita JK*. Differentiation stage-specific analysis of gene function with inducible short hair-pin RNA in differentiating embryonic stem cells. Biochem Biophys Res Commun, 351: 669-674, 2006.

  2. Yurugi-Kobayashi T, Itoh H, Schroeder T, Nakano A, Narazaki G, Kita F, Yanagi K, Hiraoka-Kanie M, Inoue E, Ara T, Nagasawa T, Just U, Nakao K, Nishikawa SI, Yamashita JK*. Adrenomedullin/cyclic AMP pathway induces Notch activation and differentiation of arterial endothelial cells from vascular progenitors. Arterioscler Thromb Vasc Biol,, 26: 1977-1984, 2006.

  3. Kono T, Kubo H*, Shimazu C, Ueda Y, Takahashi M, Yanagi K, Fujita N, Tsuruo T, Wada H, Yamashita JK*. Differentiation of lymphatic endothelial cells from embryonic stem cells on OP9 stromal cells. Arterioscler Thromb Vasc Biol, 26: 2070-2076, 2006.

  4. Nakao Y, Yoshida S, Matsunaga S, Shindoh N, Terada Y, Nagai K, Yamashita JKGanesan A, Soest van RW, Fusetani N. Azumamides A–E: Histone Deacetylase Inhibitory Cyclic Tetrapeptides from the Marine Sponge Mycale izuensis. Angew Chem Int Ed, 45: 7553-7557, 2006.[Cover image]

  5. Watabe T, Yamashita JK, Mishima K, Miyazono K. TGF-beta signaling in embryonic stem cell-derived endothelial cells. Methods Mol Biol, 330: 341-51, 2006 (Review).

2005
  1. Yamashita JK*, Takano M, Hiraoka-Kanie M, Shimazu C, Yan P, Yanagi K, Nakano A, Inoue E, Kita F, Nishikawa SI. Prospective identification of cardiac progenitor potentials by a novel single cell-based cardiomyocyte induction. FASEB J, 19: 1534-1536, 2005.

  2. Hisatsune H, Matsumura K, Ogawa M, Uemura A, Kondo N, Yamashita JK, Katsuda H, Nishikawa S, Chiba T, Nishikawa SI. A high level of endothelial cell-specific gene expression by a combination of 5’ flanking region and 5’ half of the first intron of VE-cadherin gene. Blood, 105: 4657-4663, 2005.

  3. Yamamoto K, Sokabe T, Watabe T, Miyazono K, Yamashita JKObi S, Ohmura N, Matsushita A, Kamiya A, Ando J. Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro. Am J Physiol Heart Circ Physiol, 288: H1915-1924, 2005.

  4. Huang H, Nakayama Y, Qin K, Yamamoto K, Ando J, Yamashita J, Itoh H, Kanda K, Yaku H, Okamoto Y, Nemoto Y. Differentiation from embryonic stem cells to vascular wall cells under in vitro pulsatile flow loading. J Artif Organ, 8: 110-118, 2005.

  5. Saito T, Itoh H, Yamashita J, Doi K, Chun TH, Tanaka T, Inoue M, Masatsugu K, Fukunaga Y, Sawada N, Sakaguchi S, Arai H, Tojo K, Tajima N, Hosoya T, Nakao K. Angiotensin II suppresses growth arrest specific homeobox (Gax) expression via redox-sensitive mitogen-activated protein kinase (MAPK). Regul Pept, 127: 159-167, 2005.

  6. Tanaka T, Fukunaga Y, Itoh H, Doi K, Yamashita J, Chun TH, Inoue M, Masatsugu K, Saito T, Sawada N, Sakaguchi S, Arai H, Nakao K. Therapeutic potential of thiazolidinedinoes in activation of peroxisome proliferator-activated receptor gamma for monocyte recruitment and endothelial regeneration. Eur J Pharmacol, 508: 255-265, 2005.

2004
  1. Yamashita J. Cardiovascular cell differentiation from ES cells. In: Mori H, Matsuda H. Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches. Chapter 2. p67-p80. Springer-Verlag GmbH, Berlin, New Yolk, Tokyo. 2004 (Review).

  2. Kobayashi T, Tahara Y, Matsumoto M, Iguchi M, Sano H, Maruyama T, Arai H, Oida H, Yurugi-Kobayashi T, Yamashita JK, Katagiri H, Majima M, Yokode M, Kita T, Narumiya S. Roles of thromboxane A2 and prostacyclin in development of atherosclerosis in apoE-deficient mice. J Clin Invest, 114: 784-794, 2004.

  3. Yamashita JK Differentiation and diversification of vascular cells from ES cells. Int J Hematol, 80: 1-6, 2004 (Review).

  4. Yamashita J, Nishikawa SI. Embryonic stem cell-derived endothelial cells. In: Augustin H. Springer Lab Manual. Methods in Endothelial Cell BiologyChapter 4. p33-p45. Springer-Verlag GmbH, Berlin, New Yolk, Tokyo. 2004 (Review).

  5. Suzuki Y, Komi Y, Ashino H, Yamashita J, Inoue J, Yoshiki A, Eichmann A, Amanuma H, Kojima S. Retinoic acid controls blood vessel formation by modulating endothelial and mural cell interaction via suppression of TIE2 signaling in vascular progenitor cells. Blood, 104: 166-169, 2004.

2003
  1. Fraser ST, Yamashita J, Jakt LM, Okada M, Ogawa M, Nishikawa S, Nishikawa SI. In vitro differentiation of mouse embryonic stem cells: Hematopoietic and vascular cell types. Methods Enzymol, 365: 59-72, 2003 (Review).

  2. Watabe T, Nishihara A, Mishima K, Yamashita J, Shimizu K, Miyazawa K, Nishikawa SI, Miyazono K. TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells. J Cell Biol, 163: 1303-1311, 2003.

  3. Fujita M, Nakao Y, Matsunaga S, Seiki M, Itoh Y, Yamashita J, Soest van RW, Fusetani N. Ageladine A: an anti-angiogenic matrixmetalloproteinase inhibitor from the marine sponge Agelas nakamurai. J Am Chem Soc, 125: 15700-15701, 2003.

  4. Sone M, Itoh H, Yamashita J, Yurugi-Kobayashi T, Suzuki Y, Kondo Y, Nonoguchi A, Sawada N, Yamahara K, Miyashita K, Park K, Nito S, Shibuya M, Nishikawa SI, Nakao K. Different differentiation kinetics of vascular progenitor cells in primate and mouse embryonic stem cells. Circulation, 107: 2085-2088, 2003.

  5. Yurugi-Kobayashi T, Itoh H, Yamashita J, Yamahara K, Hirai H, Kobayashi T, Ogawa M, Nishikawa S, Nishikawa SI, Nakao K. Effective contribution of transplanted vascular progenitor cells derived from embryonic stem cells to adult neovascularization in proper differentiation stage. Blood, 101: 2675-2678, 2003.

  6. Yamahara K, Itoh H, Chun TH, Ogawa Y, Yamashita J, Sawada N, Fukunaga Y, Sone M, Yurugi-Kobayashi T, Miyashita K, Tsujimoto H, Kook H, Feil R, Garbers DL, Hofmann F, NakaoK. Significance and therapeutic potential of the natriuretic peptides/cGMP/cGMP-dependent protein kinase pathway in vascular regeneration. Proc Natl Acad Sci USA, 100: 3404-3409, 2003.

  7. Masatsugu K, Itoh H, Chun TH, Saito T, Yamashita J, Doi K, Inoue M, Sawada N, Fukunaga Y, Sakaguchi S, Sone M, Yamahara K, Yurugi T, Nakao K. Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress. Regul Pept, 111: 1-3, 2003.

2002
  1. Ohono N, Itoh H, Ikeda T, Ueyama K, Yamahara K, Doi K, Yamashita J, Inoue M, Masatsugu K, Sawada N, Fukunaga Y, Sakaguchi S, Sone M, Yurugi T, Kook H, Komeda M, Nakao K. Anccelerated reendothelialization with suppressed thrombogenic property and neointimal hyperplasia of rabbit juglar vein grafts by adenovirus-mediated gene transfer of C-type atriuretic peptide. Circulation, 105: 1623-1626, 2002.

2001
  1. Doi K, Ikeda T, Itoh H, Ueyama K, Hosoda K, Ogawa Y, Yamashita J, Chun TH, Inoue M, Masatsugu K, Sawada N, Fukunaga Y, Saito T, Sone M, Yamahara K, Kook H, Komeda M, Ueda M, Nakao K. C-type natriuretic peptide induces redifferentiation of vascular smooth muscle cells with accelerated reendothelialization. Arterioscler Thromb Vasc Biol, 21: 930-936, 2001.

  2. Sawada N, Itoh H, Yamashita J, Doi K, Inoue M, Masatsugu K, Fukunaga Y, Sakaguchi S, Sone M, Yamahara K, Yurugi T, Nakao K. cGMP-dependent protein kinase phosphorylates and inactivates RhoA. Biochem Biophys Res Commun, 280: 798-805, 2001.

  3. Saito T, Itoh H, Chun TH, Fukunaga Y, Yamashita J, Doi K, Tanaka T, Inoue M, Masatsugu K, Sawada N, Sakaguchi S, Arai H, Mukoyama M, Tojo K, Hosoya T, Nakao K. Coordinate regulation of endothelin and adrenomedullin secretion by oxidative stress in endothelial cells. Am J Physiol Heart Circ Physiol, 281:H1364-71, 2001.

  4. Fukunaga Y, Itoh H, Doi K, Tanaka T, Yamashita J, Chun TH, Inoue M, Masatsugu K, Sawada N, Saito T, Hosoda K, Kook H, Ueda M, Nakao K. Thiazolidinediones, peroxisome proliferator-activated receptor gamma agonists, regulate endothelial cell growth and secretion of vasoactive peptides. Atherosclerosis, 158:113-9, 2001

2000
  1. Yamashita J*, Itoh H, Hirashima M, Ogawa M, Nishikawa S, Yurugi T, Naito M, Nakao K and Nishikawa SI. Flk1 positive cells derived from embryonic stem cells serve as vascular progenitors. Nature, 408: 92-96, 2000.

  2. Sawada N, Itoh H, Ueyama K, Yamashita J, Doi K, Chun TH, Inoue M, Masatsugu K, Saito T, Fukunaga Y, Sakaguchi S, Arai H, Ohno N, Komeda M and Nakao K. Inhibition of rho-associated kinase results in suppression of neointimal formation of balloon-injured arteries. Circulation, 101: 2030-2033, 2000.

  3. Fukunaga Y, Itoh H, Hosoda K, Doi K, Matsuda J, Son C, Yamashita J, Chun TH, Tanaka T, Inoue M, Masatsugu K, Saito T, Sawada N and Nakao K. Altered gene expression of uncoupling protein-2 and –3 in stroke-prone spontaneously hypertensive rats. J Hypertens, 18: 1233-1238, 2000.

  4. Chun TH, Itoh H, Saito T, Yamahara K, Doi K, Mori Y, Ogawa Y, Yamashita J, Tanaka T, Inoue M, Masatsugu K, Sawada N, Fukunaga Y and Nakao K. Oxidative stress augments secretion of endothelium-derived relaxing peptides, C-type natriuretic peptide and adrenomedullin. J Hypertens, 18: 575-580, 2000.

1999-
  1. Tanaka T, Itoh H, Doi K, Fukunaga Y, Hosoda K, Shintani M, Yamashita J, Chun TH, Inoue M, Masatsugu K, Sawada N, Saito T, Inoue G, Nishimura H, Yoshimasa Y and Nakao K. Down regulation of peroxisome proliferator-activated receptor gamma expression by inflammatory cytokines and its reversal by thiazolidinediones. Diabetologia, 42: 702-710, 1999.

  2. Yamashita J, Yoshimasa T, Arai H, Hiraoka J, Takaya K, Miyamoto Y, Ogawa Y, Itoh H and Nakao K. Identification of cis-elements of the human endothelin-A receptor gene and inhibition of the gene expression by the decoy strategy. J Biol Chem, 273: 15993-15999, 1998.

  3. Inoue M, Itoh H, Ueda M, Naruko T, Kojima A, Komatsu R, Doi K, Ogawa Y, Tamura N, Takaya K, Igaki T, Yamashita J, Chun TH, Masatsugu K, Becker AE and Nakao. Vascular endothelial growhth factor (VEGF) expression in human coronary artery atherosclerotic lesions: possible pathophysiological significance of VEGF in progression of atherosclerosis. Circulation, 98: 2108-2116, 1998.

  4. Suga SI, Itoh H, Komatsu Y, Ishida H, Igaki T, Yamashita J, Doi K, Chun TH, Yoshimasa T, Tanaka I and Nakao K. Regulation of endothelial production of C-type natriuretic peptide by interaction between endothelial cells and macrophages. Endocrinology, 139: 1920-1926, 1998.

  5. Saito T, Itoh H, Chun T, Igaki T, Mori Y, Yamashita J, Doi K, Tanaka T, Inoue M, Masatsugu K, Fukunaga Y, Sawada N, Tojo K, Saito Y, Hosoya T, Nakao K. Oxidative stress suppresses the endothelial secretion of endothelin. J Cardiovasc Pharmacol, 31 Suppl 1: 345-7, 1998.

  6. Masatsugu K, Itoh H, Chun TH, Ogawa Y, Tamura N, Yamashita J, Doi K, Inoue M, Fukunaga Y, Sawada N, Saito T, Korenaga R, Ando J, Nakao K. Phiysiologic shear stress suppresses endothelin-converting enzyme-1 expression in vascular endothelial cells. J Cardiovasc Pharmacol, 31 Suppl 1: 42-5, 1998

  7. Igaki T, Itoh H, Suga SI, Hama N, Ogawa Y, Komatsu Y, Yamashita J, Doi K, Chun TH, Nakao K. Effects of intravenously administered C-type natriuretic peptide in humans: comparison with atrial natriuretic peptide. Hypertens Res, 21:7-13, 1998.

  8. Yamashita J, Itoh H, Ogawa Y, Tamura N, Takaya K, Igaki T, Doi K, Chun TH, Inoue M, Masatsugu K and Nakao K. Opposite regulation of Gax homeobox expression by angiotensin II and C-type natriuretic peptide. Hypertension, 29: 381-387, 1997.

  9. M Harada, Itoh H, Nakagawa O, Ogawa Y, Miyamoto Y, Kuwahara K, Ogawa E, Igaki T, Yamashita J, Masuda I, Yoshimasa T, Tanaka I, Saito Y and Nakao K. Significance of ventricular myocytes and nonmyocytes interaction during cardiocyte hypertrophy -- Evidence for endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytes. Circulation, 96: 3737-44, 1997.

  10. Itoh H, Suga S, Ogawa Y, Komatsu Y, Tamura N, Igaki T, Yamashita J, Ikeda T, Doi K, Chun TH, Inoue M, Matsuda K, Yoshimasa T, Ueda M, Ban T and Nakao K. Significance of vascular natriuretic peptide system in vascular remodeling in humans and its application to gene therapy. Ann NY Acad Sci, 811: 533-541, 1997 (Review).

  11. Chun T.H, Itoh H, Ogawa Y, Tamura N, Takaya K, Igaki T, Yamashita J, Doi K, Inoue M, Masatsugu K, Korenaga R, Ando J and Nakao K. Shear stress augments expression of C-type natriuretic peptide and adrenomedullin. Hypertension, 29: 1296-1302, 1997.

  12. Doi K, Itoh H, Ikeda T, Hosoda K, Ogawa Y, Igaki T, Yamashita J, Chun TH, Inoue M, Masatsugu K, Matsuda K, Ohmori K and Nakao K. Adenovirus mediated gene transfer of C-type natriuretic peptide causes G1 growth inhibition of cultured vascular smooth muscle cells. Biochem Biophys Res Commun, 239: 889-94, 1997.

  13. Doi K, Itoh H, Nakagawa O, Igaki T, Yamashita J, Chun TH, Inoue M, Masatsugu K and Nakao K. Expression of natriuretic peptide system during embryonic stem cell vasculoangiogenesis -- Natriuretic peptides in ES cell vasculoangiogenesis. Heart Vessels Suppl, 12:18-22, 1997.

  14. Itoh H, Suga S, Ogawa Y, Komatsu Y, Tamura N, Igaki T, Yamashita J, Doi K, Chun TH, Inoue M, Masatsugu K, Ikeda T, Shirakami G, Matsuda K, Katsuura G, Ueda M, Ban T, Nakao K. Cellular and molecular aspects of C-type natriuretic peptide. In: Samson WK and Levin ER: Contemporary Endocrinology: Natriuretic Peptides in Health and Disease. Humana Press Inc., Totowa, NJ. 1997 (Review).

  15. Doi K, Itoh H, Komatsu Y, Igaki T, Chun TH, Takaya K, Yamashita J, Inoue M, Yoshimasa T and Nakao K. Vascular endothelial growth factor suppresses C-type natriuretic peptide secretion. Hypertension, 27:3 Pt 2: 811-815, 1996.

  16. Yamashita J, Yoshimasa T, Arai H, Hiraoka J, Takaya K, Miyamoto Y, Ogawa Y, Itoh H and Nakao K. Cis elements for transcriptional regulation of the human endothelin-A receptor gene. J Cardiovasc Pharmacol, 26 (Suppl. 3): S26-S28, 1995.

  17. Hiraoka J, Arai H, Yoshimasa T, Takaya K, Miyamoto Y, Yamashita J, Suga S, Ogawa Y, Shirakami G, Itoh H. Augmented expression of the endothelin-A receptor gene in cultured mesangial cells from stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol, 22: S191-192, 1995.

  18. Kishimoto I, Yoshimasa T, Arai H, Takaya K, Miyamoto Y, Yamashita J, Suga S, Komatsu Y, Nakagawa O, Tanaka I. Endothelin-induced activation of mitogen-activated protein kinases in glomerular mesangial cells from normotensive and stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol, 22: S207-S208, 1995.

和文総説
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  3. 山下 潤.「血管を構成する細胞系譜とその分化」血管新生研究の最前線(佐藤靖史、高倉伸幸・編)p22-p33, 2013. 医薬ジャーナル社

  4. 山下 潤.「心筋再生医療」Annual Review循環器2013, p41-p50. 中外医学社

  5. 山下 潤.「低分子化合物によるES/iPS細胞由来心筋細胞の分化・増殖制御」循環器内科・特集「心筋再生医療の最前線」71: 338-345, 2012. 科学評論社

  6. 山下 潤. 「多能性幹細胞を用いた心臓再生 創薬アプローチを中心に」, ファルマシア, 48: p847-851, 2012. 日本薬学会

  7. 山下 潤. 「血管の発生と分化メカニズム」, 血管医学 Vol.13/No.4: p77-84, 2012. メディカルレビュー社

  8. 升本 英利、山下 潤. 「純化心血管系細胞の再構成による多能性幹細胞由来細胞シートは心筋細胞を介する血管新生により梗塞心の機能を回復させる」, Vol.11/No.4: p56-62, 2012. 日本再生医療学会

  9. 山下 潤.「内皮細胞分化」血管生物医学事典(日本血管生物医学会・編)第3章, p158-159, 2011.朝倉書店

  10. 山水康平、山下 潤.「動静脈分化」血管生物医学事典(日本血管生物医学会・編)第3章, p166-167, 2011.朝倉書店

  11. 山水康平、山下 潤.「血管ガイダンス」血管生物医学事典(日本血管生物医学会・編)第3章, p170-171, 2011.朝倉書店

  12. 山下 潤.「CXCL12/CXCR4」血管生物医学事典(日本血管生物医学会・編)第4章, p257-258, 2011.朝倉書店

  13. 山下 潤.「iPS細胞からの心筋分化・血管分化」医学の歩み別冊「次世代iPS医療」(梅澤明弘・企画)239, 1416-1421, 2011

  14. 山下 潤.「ES細胞とiPS細胞からの心筋再生」循環器再生医学の現状と展望(室原豊明・編)Chapter 3, p115-124, 2011. メディカルレビュー社

  15. 山下 潤.「ES細胞/iPS細胞を用いた心血管再生はどこまできたか」Heart View特集「血管・心筋再生はどこまできたか」15: 40-45, 2011

  16. 山下 潤.「iPS細胞を用いた心筋再生」心臓「iPS細胞の循環器疾患への応用」企画:山下 潤. 43: 3-9, 2011

  17. 山水康平、山下 潤.「血管発生のメカニズム:内皮細胞の分化と動静脈形成」細胞工学「血管新生を制御する」29: 1075-1081, 2010

  18. 山下 潤.「iPS細胞の発見が心血管再生医学研究に与えるインパクト」Cardiac Practice 特集「心血管系の再生医学」21: 17-22, 2010

  19. 山下 潤.「血管内皮細胞の発生・分化-血管多様性研究のプロローグ」実験医学増刊「血管研究と血管治療」28: 28-35, 2010. 羊土社

  20. 山下 潤.「iPS細胞の展望」Cardiovascular Frontier別冊「特集再生医療」1: 111-117, 2010

  21. 山下 潤.「心不全に対するiPS細胞の臨床応用」医学の歩み「心不全 -研究と臨床の最前線-」 232: 559-605, 2010. 医歯薬出版

  22. 山下 潤.「血管再生」綜合臨床 58: 72-78, 2009. 永井書店

  23. 山下 潤.「iPS細胞による血管再生治療の展望」細胞「特集血管の発生と再生」 41: 18-21, 2009. ニューサイエンス社

  24. 山下 潤.「iPS細胞研究の現状と展望」循環器科・特集「循環器疾患の再生医療update」66: 472-480, 2009.科学評論社

  25. 山下 潤.「iPS細胞からの心血管細胞の分化誘導とその応用」臨床検査53: 1097-1103, 2009. 医学書院

  26. 山下 潤.「iPS細胞研究の現状と展望」分子血管病・特集「幹細胞研究の新展開」10: 18-26, 2009.先端医学社

  27. 山下 潤.「ES細胞およびiPS細胞からの血管細胞分化」再生医療8: 28-33, 2009. 日本再生医療学会雑誌

  28. 山下 潤.「ES細胞、iPS細胞を用いた血管再生医療技術」幹細胞の分化誘導と応用 - ES細胞・iPS細胞・体性幹細胞研究最前線-. 第3章p253-261, 2009. NTS.

  29. 山下 潤.「iPS細胞と心血管再生」Annual Review循環器2009. p1-p9, 2009. 中外医学社

  30. 山下 潤.「ES細胞・iPS細胞からの血管・リンパ管内皮細胞分化」分子細胞治療 7: 22-28, 2008

  31. 山下 潤.「iPS細胞を用いた血管再生」CLINICIAN「再生医療を考える」56: 61-74, 2008. エーザイ株式会社

  32. 山下 潤. 「ES細胞による血管の分化再生」遺伝子医学MOOK別冊「進み続ける細胞移植治療の実際」田畑泰彦編, p107-p111, 2008. メディカルドゥ社

  33. 山下 潤.「ES細胞からの血管分化・多様化と血管再生」医学の歩み「Vascular Biology Update」 223: 960-965, 2007. 医歯薬出版

  34. 山下 潤.「血管とリンパ管の分化と新生」炎症と免疫 15: 37-42, 2007.先端医学社

  35. 山下 潤.「心血管細胞分化再生研究の最前線」治療・別冊「再生医学のいま」89: 1733-1740, 2007. 南山堂

  36. 山下 潤.「ヒトES細胞を用いた心血管細胞分化機構に関する研究」医学のあゆみ「ヒトES細胞研究のネクストステージ」 220: 175-180, 2007. 医歯薬出版

  37. 山下 潤. 「ES細胞と血管再生」 生体の科学・特集血管壁, 57: 590-592, 2006. 医学書院

  38. 山下 潤.「血管内皮細胞分化多様化のメカニズム」実験医学増刊「急速進展する血管研究」宮園浩平、佐藤靖史編, p25-p32, 2006. 羊土社

  39. 山下 潤. 「血管とリンパ管の発生」渋谷正史編「癌と血管新生の分子生物学」, p15-p26, 2006. 南山堂

  40. 山下 潤. 「ES細胞を用いた血管分化再生研究」脈管学, 46: 265-271, 2006. 日本脈管学会

  41. 山下 潤. 「胚性幹細胞からの血管分化と再生」循環器科, 60: 59-65, 2006. 科学評論社

  42. 山下 潤. 「血管発生のメカニズム」人工臓器・再生医療の最先端、許俊鋭・斎藤明・赤池敏宏編, p144-p149, 2005. 先端医療技術研究所

  43. 山下 潤. 「血管の発生と分化メカニズム -血管構成細胞分化多様化の視点から-」実験医学, 23: 2425-2430, 2005. 羊土社

  44. 山下 潤. 「ES細胞を用いた心血管細胞分化誘導と心血管再生」再生医療, 4: 47-53, 2005. 日本再生医療学会

  45. 山下 潤. 「血管の発生と分化」治療学, 39: 9-14, 2005. ライフサイエンス出版

  46. 山下 潤. 「ES細胞に関する研究の進歩」循環器専門医, 13: 10-16, 2005. 日本循環器学会

  47. 山下 潤. 「血管系の発生とその制御」Molecular Medicine, 42: 618-626, 2005. 中山書店

  48. 山下 潤. 「ES細胞を用いた血管新生」血管医学, 5: 25-32, 2004. メディカルレビュー社

  49. 山下 潤. 「血管壁の構造と発生」血管不全フロンティア、野出孝一編, 35p-44p, 2004. メディカルレビュー社

  50. 山下 潤. 「nicheにおける未分化性の維持」遺伝子医学MOOK「再生医療へのブレイクスルー」田畑泰彦編, 94p-99p, 2004. メディカルドゥ社

  51. 山下 潤. 「ヒトES細胞分化誘導と移植への応用」細胞工学, 23: 1264-1267, 2004. 秀潤社

  52. 山下 潤. 「ES細胞を用いた血管再生の今後の展開」わかる実験医学シリーズ「血管研究がわかる」高倉伸幸編, 123p-128p, 2004. 羊土社

  53. 山下 潤. 「再生医療と血管分化制御機構」分子血管病, 5: 36-43, 2004. 先端医学社

  54. 山下 潤. 「ES細胞を用いた血管形成」メディカル・サイエンス・ダイジェスト, 30: 12-15, 2004. ニューサイエンス社

  55. 山下 潤.「血管内皮細胞と平滑筋細胞はどのように分化するか」第17回「大学と科学」シンポジウム「21世紀に動脈硬化はこうして予防しこうして治療する」87p-93p, 2003. クバプロ

  56. 山下 潤. 「ES細胞を用いた血管の分化・多様化機構と血管再生」Therapeutic Research. 24: 2148-2157, 2003. ライフサイエンス出版

  57. 山下 潤. 「ヒトES細胞の樹立・分化研究と再生医療応用」病理と臨床, 21: 698-702, 2003. 文光堂

  58. 山下 潤. 総説「幹細胞・ES細胞-血管」再生医療, 2: 111-119, 2003. 日本再生医療学会

  59. 山下 潤. 「ヒトES細胞と再生医療」血液・免疫・腫瘍, 8: 19-26, 2003. メディカルレビュー社

  60. 山下 潤. 「ES細胞を用いたin vitro血管分化系 ? 分化制御研究の新たな視点 -」炎症・再生, 6: 509-518, 2002. 日本炎症・再生医学会

  61. 山下 潤. 「ES細胞から血管を再生する」Heart View, 6: 45-51, 2002. メジカルビュー社

  62. 山下 潤. 「循環器:心血管系の再生医学」最新医学9月増刊号 臨床遺伝子学02, 2002. 最新医学社

  63. 山下 潤. 「ES細胞を用いた血管研究」血管医学, 3: 015-024, 2002. メディカルレビュー社

  64. 山下 潤. 「血管発生の分子生物学」細胞, 34: 4-9, 2002. ニュー・サイエンス社

  65. 山下 潤. 「血管発生・血管新生研究」分子心血管病, 3: 97-103, 2002. 先端医学社

  66. 山下 潤. 「ES細胞からの血管発生と再生医学」Atherothrombosis, 5: 39-41, 2002. メジカルセンス社

  67. 山下 潤. 「ES細胞からの心血管分化」 小室一成編. 目で見る循環器病フロンティア, p37-p43, 2002. メジカルビュー社

  68. 山下 潤. 「血管細胞系譜決定のメカニズム」 医学の歩み 199: 966-972, 2001. 医歯薬出版

  69. 山下 潤. 「ES細胞からの血管形成 - 血管発生機構の解析における新たな視点と血管再生治療への応用 -」 実験医学 19: 830-835, 2001. 羊土社

  70. 山下 潤、小川峰太郎、中尾一和、西川伸一. 「血管壁細胞の発生・分化」 医学の歩み 194: 725-730, 2000. 医歯薬出版

  71. 山下 潤、伊藤 裕、西川伸一、中尾一和. 「血管前駆細胞の同定と血管再生への応用」 最新医学 54:2775-2784, 1999. 最新医学社

  72. 山下 潤、伊藤 裕、中尾一和.「高血圧を伴う高脂血症」内科<種々の病態における高脂血症-診療の実際> 81: 319-322, 1998

  73. 山下 潤、伊藤 裕、中尾一和.「ナトリウム利尿ペプチドの血管平滑筋細胞増殖・分化における意義と遺伝子治療への応用」医学のあゆみ 182: 360-364, 1997

  74. 山下 潤、伊藤 裕、中尾一和.「エンドセリンの関与」内分泌・糖尿病科 特集「動脈硬化症の内分泌学」4: 515-521, 1997

  75. 山下 潤、伊藤 裕、中尾一和. 高脂血症の合併症に注目した診療の実際「高血圧をみたら」Medical Practice 14: 595-598, 1997

  76. 山下 潤、伊藤 裕、中尾一和:ナトリウム利尿ペプチド系, 赤沼安夫 他編:別冊医学のあゆみ「内分泌・代謝疾患」-State of Arts- 医歯薬出版、東京、1997

  77. 吉政孝明、荒井宏司、高屋和彦、宮本恵宏、山下 潤、中尾一和.「エンドセリン受容体の構造と発現」現代医療 27: 83-87, 1995

  78. 荒井宏司、吉政孝明、高屋和彦、宮本恵宏、山下 潤、中尾一和.「エンドセリン受容体の構造と発現調節」現代医療 27: 19-24, 1995