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胚性幹細胞研究分野:業績 (2007年〜)

Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato SI, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M.
A Chemical Probe that Labels Human Pluripotent Stem Cells.
Cell Rep. Mar 4 (2014).

Miyazaki T, Nakatsuji N, Suemori H.
Optimization of slow cooling cryopreservation for human pluripotent stem cells.
Genesis 52(1): 49-55 (2014).

Kazuki Y, Yakura Y, Abe S, Osaki M, Kajitani N, Kazuki K, Takehara S, Honma K, Suemori H, Yamazaki S, Sakuma T, Toki T, Shimizu R, Nakauchi H, Yamamoto T, Oshimura M.
Down syndrome-associated haematopoiesis abnormalities created by chromosome transfer and genome editing technologies.
Sci Rep. 27;4:6136 (2014).

Igawa K, Kokubu C, Yusa K, Horie K, Yoshimura Y, Yamauchi K, Suemori H, Yokozeki H, Toyoda M, Kiyokawa N, Okita H, Miyagawa Y, Akutsu H, Umezawa A, Katayama I, Takeda J.
Removal of reprogramming transgenes improves the tissue reconstitution potential of keratinocytes generated from human induced pluripotent stem cells.
Stem Cells Transl Med. 3(9):992-1001 (2014).

Hatori M, Shimozawa N, Yasmin L, Suemori H, Nakatsuji N, Ogura A, Yagami K, Sankai T.
Role of retinoic acid and fibroblast growth factor 2 in neural differentiation from cynomolgus monkey (macaca fascicularis) embryonic stem cells.
Comp Med. 64(2):140-7 (2014).

Takeuchi H, Nakatsuji N, Suemori H.
Endodermal differentiation of human pluripotent stem cells to insulin-producing cells in 3D culture.
Sci Rep. 27;4:4488 (2014).

Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato S, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, UedaK, Uesugi M.
A chemical probe that labels human pluripotent stem cells.
Cell Rep. 27;6(6):1165-74 (2014).

Kuo T-F, Mao D, Hirata N, Khambu B, Kimura Y, Kawase E, Shimogawa H, Ojika M, Nakatsuji N, Ueda K, Uesugi M.
Selective elimination of human pluripotent stem cells by a marine natural product derivative.
Journal of the American Chemical Society, 136, 9798-801 (2014).

Kumagai H, Suemori H, Uesugi M, Nakatsuji N, Kawase E.
Identification of small molecules that promote human embryonic stem cell self-renewal.
Biochem Biophys Res Commun. Vol.4, 434 (2013) pp. 710-716

Takase O, Yoshikawa M, Idei M, Hirahashi J, Fujita T, Takato T, Isagawa T, Nagae G, Suemori H, Aburatani H, Hishikawa K.
The Role of NF-κB Signaling in the Maintenance of Pluripotency of Human Induced Pluripotent Stem Cells.
PLoS One. 2013;8(2):e56399. doi: 10.1371/journal.pone.0056399. Epub 2013 Feb 20.

Miyazaki T, Futaki S, Suemori H, Taniguchi Y, Yamada M, Kawasaki M, Hayashi M, Kumagai H, Nakatsuji N, Sekiguchi K, Kawase E.
Laminin E8 fragments support efficient adhesion and expansion of dissociated human pluripotent stem cells.
Nat Commun. 2012;3:1236. doi: 10.1038/ncomms2231.

Hasegawa K, Yasuda SY, Teo JL, Nguyen C, McMillan M, Hsieh CL, Suemori H, Nakatsuji N, Yamamoto M, Miyabayashi T, Lutzko C, Pera MF, Kahn M.
Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion.
Stem Cells Transl Med. 2012 Jan;1(1):18-28. doi: 10.5966/sctm.2011-0033. Epub 2011 Dec 7.

Tsuneyoshi N, Tan EK, Sadasivam A, Poobalan Y, Sumi T, Nakatsuji N, Suemori H, Dunn NR.
The SMAD2/3 corepressor SNON maintains pluripotency through selective repression of mesendodermal genes in human ES cells.
Genes Dev. 2012 Nov 15;26(22):2471-6. doi: 10.1101/gad.201772.112.

Otsuji TG, Kurose Y, Suemori H, Tada M, Nakatsuji N.
Dynamic link between histone H3 acetylation and an increase in the functional characteristics of human ESC/iPSC-derived cardiomyocytes.
PLoS One. 2012;7(9):e45010. doi: 10.1371/journal.pone.0045010. Epub 2012 Sep 12.

Kamimura R, Ishii T, Sasaki N, Kajiwara M, Machimoto T, Saito M, Kohno K, Suemori H, Nakatsuji N, Ikai I, Yasuchika K, Uemoto S.
Comparative study of transplantation of hepatocytes at various differentiation stages into mice with lethal liver damage.
Cell Transplant. 2012 Apr 2. [Epub ahead of print]

Doi D, Morizane A, Kikuchi T, Onoe H, Hayashi T, Kawasaki T, Motono M, Sasai Y, Saiki H, Gomi M, Yoshikawa T, Hayashi H, Shinoyama M, Refaat MM, Suemori H, Miyamoto S, Takahashi J.
Prolonged maturation culture favors a reduction in the tumorigenicity and the dopaminergic function of human ESC-derived neural cells in a primate model of Parkinson's disease.
Stem Cells. 2012 May;30(5):935-45. doi: 10.1002/stem.1060.

Aizawa E, Hirabayashi Y, Iwanaga Y, Suzuki K, Sakurai K, Shimoji M, Aiba K, Wada T, Tooi N, Kawase E, Suemori H, Nakatsuji N, Mitani K.
Efficient and accurate homologous recombination in hESCs and hiPSCs using helper-dependent adenoviral vectors.
Mol Ther. 2012 Feb;20(2):424-31. doi: 10.1038/mt.2011.266. Epub 2011 Dec 6.

International Stem Cell Initiative, Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y, Ward-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q.
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.
Nat Biotechnol. 2011 Nov 27;29(12):1132-44. doi: 10.1038/nbt.2051.

Sasaki N, Ishii T, Kamimura R, Kajiwara M, Machimoto T, Nakatsuji N, Suemori H, Ikai I, Yasuchika K, Uemoto S.
Alpha-fetoprotein-producing pancreatic cancer cells possess cancer stem cell characteristics.
Cancer Lett. 2011 Sep 28;308(2):152-61.

Nagae G, Isagawa T, Shiraki N, Fujita T, Yamamoto S, Tsutsumi S, Nonaka A, Yoshiba S, Matsusaka K, Midorikawa Y, Ishikawa S, Soejima H, Fukayama M, Suemori H, Nakatsuji N, Kume S, Aburatani H.
Tissue-specific demethylation in CpG-poor promoters during cellular differentiation.
Hum Mol Genet. 2011 Jul 15;20(14):2710-21.

Tatsumi R, Suzuki Y, Sumi T, Sone M, Suemori H, Nakatsuji N.
Simple and highly efficient method for production of endothelial cells from human embryonic stem cells.
Cell Transplant. 2011;20(9):1423-30.

Yamauchi K, Sumi T, Minami I, Otsuji TG, Kawase E, Nakatsuji N, Suemori H.
Cardiomyocytes develop from anterior primitive streak cells induced by β-catenin activation and the blockage of BMP signaling in hESCs.
Genes Cells. 2010 Dec;15(12):1216-27.

Morishima T, Watanabe K, Niwa A, Fujino H, Matsubara H, Adachi S, Suemori H, Nakahata T, Heike T.
Neutrophil differentiation from human-induced pluripotent stem cells.
J Cell Physiol. 2011 May;226(5):1283-91.

Ohgushi M, Matsumura M, Eiraku M, Murakami K, Aramaki T, Nishiyama A, Muguruma K, Nakano T, Suga H, Ueno M, Ishizaki T, Suemori H, Narumiya S, Niwa H, Sasai Y.
Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells.
Cell Stem Cell. 2010 Aug 6;7(2):225-39. 

Adachi K, Suemori H, Yasuda SY, Nakatsuji N, Kawase E.
Role of SOX2 in maintaining pluripotency of human embryonic stem cells.
Genes Cells. 2010 May; 15(5) 455-70

International Stem Cell Initiative Consortium, Akopian V, Andrews PW, Beil S, Benvenisty N, Brehm J, Christie M, Ford A, Fox V, Gokhale PJ, Healy L, Holm F, Hovatta O, Knowles BB, Ludwig TE, McKay RD, Miyazaki T,
Nakatsuji N, Oh SK, Pera MF, Rossant J, Stacey GN, Suemori H.
Comparison of defined culture systems for feeder cell free propagation of human embryonic stem cells.
In Vitro Cell Dev Biol Anim. 2010 Apr;46(3-4):247-58.

Ishii T, Yasuchika K, Suemori H, Nakatsuji N, Ikai I, Uemoto S.
Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma.
Cancer Lett. 2010 Aug 1; 294(1) 25-34

Sakurai K, Shimoji M, Tahimic CG, Aiba K, Kawase E, Hasegawa K, Amagai Y, Suemori H, Nakatsuji N.
Efficient integration of transgenes into a defined locus in human embryonic stem cells.
Nucleic Acids Res. 2010 Apr 1;38(7):e96.

Ishii T, Yasuchika K, Fukumitsu K, Kawamoto T, Kawamura-Saitoh M, Amagai Y, Ikai I, Uemoto S, Kawase E, Suemori H, Nakatsuji N.
In vitro hepatic maturation of human embryonic stem cells by using a mesenchymal cell line derived from murine fetal livers.
Cell Tissue Res. 2010 Mar;339(3):505-12.

Taura D, Noguchi M, Sone M, Hosoda K, Mori E, Okada Y, Takahashi K, Homma K, Oyamada N, Inuzuka M, Sonoyama T, Ebihara K, Tamura N, Itoh H, Suemori H, Nakatsuji N, Okano H, Yamanaka S, Nakao K.
Adipogenic differentiation of human induced pluripotent stem cells: comparison with that of human embryonic stem cells.
FEBS Lett. 2009 Mar 18;583(6):1029-33 (2009)

Suzuki K, Mitsui K, Aizawa E, Hasegawa K, Kawase E, Yamagishi T, Shimizu Y, Suemori H, Nakatsuji N, Mitani K.
Highly efficient transient gene expression and gene targeting in primate embryonic stem cells with helper-dependent adenoviral vectors.
Proc Natl Acad Sci U S A. Sep 16;105(37):13781-6 (2008)
 
Tsuneyoshi N, Sumi T, Onda H, Nojima H, Nakatsuji N, Suemori H.
PRDM14 suppresses expression of differentiation marker genes in human embryonic stem cells.
Biochem Biophys Res Commun.Mar 21;367(4):899-905(2008)

Ma F, Kambe N, Wang D, Shinoda G, Fujino H, Umeda K, Fujisawa A, Ma L, Suemori H, Nakatsuji N, Miyachi Y, Torii R, Tsuji K, Heike T, Nakahata T.
Direct Development of Functionally Mature Tryptase/chymase Double Positive Connective Tissue-Type Mast Cells from Primate ES Cells.
Stem Cells. Mar;26(3):706-14(2008)

Ishii T, Yasuchika K, Machimoto T, Kamo N, Komori J, Konishi S, Suemori H, Nakatsuji N, Saito M, Kohno K, Uemoto S, Ikai I.
Transplantation of embryonic stem cell-derived endodermal cells into mice with induced lethal liver damage.
Stem Cells. Dec;25(12):3252-60(2007).

Sone M, Itoh H, Yamahara K, Yamashita JK, Yurugi-Kobayashi T, Nonoguchi A, Suzuki Y, Chao TH, Sawada N, Fukunaga Y, Miyashita K, Park K, Oyamada N, Sawada N, Taura D, Tamura N, Kondo Y, Nito S, Suemori H, Nakatsuji N, Nishikawa S, Nakao K.
Pathway for differentiation of human embryonic stem cells to vascular cell components and their potential for vascular regeneration.
Arterioscler Thromb Vasc Biol. Oct;27(10):2127-34(2007).

Senju S, Suemori H, Zembutsu H, Uemura Y, Hirata S, Fukuma D, Matsuyoshi H, Shimomura M, Haruta M, Fukushima S, Matsunaga Y, Katagiri T, Nakamura Y, Furuya M, Nakatsuji N, Nishimura Y.
Genetically manipulated human embryonic stem cell-derived dendritic cells with immune regulatory function.
Stem Cells. Nov;25(11):2720-9 (2007).


The International Stem Cell Initiative*, Adewumi O, Aflatoonian B, Ahrlund-Richter L, Amit M, Andrews PW, Beighton G, Bello PA, Benvenisty N, Berry LS, Bevan S, Blum B, Brooking J, Chen KG, Choo AB, Churchill GA, Corbel M, Damjanov I, Draper JS, Dvorak P, Emanuelsson K, Fleck RA, Ford A, Gertow K, Gertsenstein M, Gokhale PJ, Hamilton RS, Hampl A, Healy LE, Hovatta O, Hyllner J, Imreh MP, Itskovitz-Eldor J, Jackson J, Johnson JL, Jones M, Kee K, King BL, Knowles BB, Lako M, Lebrin F, Mallon BS, Manning D, Mayshar Y, McKay RD, Michalska AE, Mikkola M, Mileikovsky M, Minger SL, Moore HD, Mummery CL, Nagy A, Nakatsuji N, O'brien CM, Oh SK, Olsson C, Otonkoski T, Park KY, Passier R, Patel H, Patel M, Pedersen R, Pera MF, Piekarczyk MS, Pera RA, Reubinoff BE, Robins AJ, Rossant J, Rugg-Gunn P, Schulz TC, Semb H, Sherrer ES, Siemen H, Stacey GN, Stojkovic M, Suemori H, Szatkiewicz J, Turetsky T, Tuuri T, van den Brink S, Vintersten K, Vuoristo S, Ward D, Weaver TA, Young LA, Zhang W.
Characterization of human embryonic stem cell lines by the International Stem Cell Initiative.
Nat Biotechnol. Jul;25(7):803-16 (2007).

Sato H, Suemori H, Toguchida J, Iwata H.
Recombinant matrix protein for maintenance of undifferentiated primate embryonic stem cells.
Tissue Eng. Jul;13(7):1539-47 (2007).

Hasegawa K, Cowan AB, Nakatsuji N, Suemori H.
Efficient multicistronic expression of a transgene in human embryonic stem cells.
Stem Cells. Jul;25(7):1707-12(2007).

Sumi T, Tsuneyoshi N, Nakatsuji N, Suemori H.
Apoptosis and differentiation of human embryonic stem cells induced by sustained activation of c-Myc.
Oncogene. Mar 19. Aug 16;26(38):5564-76 (2007).

Hosseinkhani M, Hasegawa K, Ono K, Kawamura T, Takaya T, Morimoto T, Wada H, Shimatsu A, Prat SG, Suemori H, Nakatsuji N, Kita T.
Trichostatin A induces myocardial differentiation of monkey ES cells.
Biochem Biophys Res Commun. May 4;356(2):386-91(2007).

Shinoda G, Umeda K, Heike T, Arai M, Niwa A, Ma F, Suemori H, Luo HY, Chui DH, Torii R, Shibuya M, Nakatsuji N, Nakahata T.
alpha4-Integrin(+) endothelium derived from primate embryonic stem cells generates primitive and definitive hematopoietic cells.
Blood. Mar 15;109(6):2406-15 (2007).

2002-2006年の業績はこちら。
旧細胞プロセシング研究領域の業績はこちら。

(C)2012, Lab. of Embyonic Stem Cell Res., Inst. for Frontier Med. Sci., Kyoto-u All Rights Reserved
Last Update on 2012.6.1