>>Reference to project 2

>>Reference to 1982`2000

yProject 1z

Wing K, and Sakaguchi S. Regulatory T cells exert checks and balances on self-tolerance and autoimmunity. Nat. Immunol. 11:7-13, 2010

Onodera T, Jang MH, Guo Z, Yamasaki M, Hirata T, Bai Z, Tsuji NM, Nagakubo D, Yoshie O,
Sakaguchi S, Takikawa O, Miyasaka M.
@Constitutive expression of IDO by dendritic cells of mesenteric lymph nodes: functional involvement of the CTLA-4/B7 and CCL22/CCR4 interactions. J. Immunol. 183:5608-5614, 2009.

Sakaguchi S
, Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T. Regulatory T cells: how do they suppress immune responses? Int. Immunol. 21:1105-11, 2009.

Kitoh, A., Ono, M., Naoe, Y., Ohkura, N., Yamaguchi, T, Yaguchi, H., Kitabayashi, I., Tsukada, T., Nomura, T., Miyachi,Y., Taniuchi, I., and Sakaguchi, S. Indispensable role of Runx1/Cbfƒΐ complexes for in vivo suppressive function of FoxP3+ regulatory T cells. Immunity.
31:609-620, 2009.

Sakaguchi, S., Wing, K., and Yamaguchi, T. Dynamics of peripheral tolerance and immune regulation. Eur. J. Immunol. 39(9):2331-6, 2009.

Okamura T, Fujio K, Shibuya M, Sumitomo S, Shoda H, Sakaguchi S, Yamamoto K. CD4+CD25-LAG3+ regulatory T cells controlled by the transcription factor Egr-2. Proc Natl Acad Sci U S A. 106:13974-9, 2009.

Piao J, Kamimura Y, Iwai H, Cao Y, Kikuchi K, Hashiguchi M, Masunaga T, Jiang H, Tamura K, Sakaguchi S, Azuma M. Enhancement of T-cell-mediated anti-tumour immunity via the ectopically expressed glucocorticoid-induced tumour necrosis factor receptor-related receptor ligand (GITRL) on tumours. Immunology. 127:489-99, 2009.

Miyara, M., Wing, K., and Sakaguchi, S. Therapeutic approaches to allergy and autoimmunity based on FoxP3+ regulatory T-cell activation and expansion. J Allergy Clin Immunol. 123:749-55, 2009.

Liu, Z., Tian, S., Falo, L. D. Jr, Sakaguchi, S., and You, Z. Therapeutic Immunity by Adoptive Tumor-primed CD4(+) T-cell Transfer in Combination With In Vivo GITR Ligation. Mol Ther. 17:1274-81, 2009.

Duan F, Lin Y, Liu C, Engelhorn ME, Cohen AD, Curran M, Sakaguchi S, Merghoub T, Terzulli S, Wolchok JD, Houghton AN. Immune rejection of mouse tumors expressing mutated self. Cancer Res. 69:3545-3553, 2009.

Ohkura, N,. and
Sakaguchi, S. A novel modifier of regulatory T cells Nat Immunol. 10: 685-686, 2009.

Miyara, M., Shima, T., Kitoh, A., Yoshioka, Y., Niwa, A., Taflin, C., Heike, T., Valeyre, D., Mathian, A., Nakahata, T., Yamaguchi T., Nomura, T., Wing, K., Ono, M., Amoura, Z., Guy Gorochov, G., and Sakaguchi, S. Functional delineation and differentiation dynamics of human CD4(+) T Cells expressing the Foxp3 transcription factor.Immunity. 30:899-911, 2009

Nagahama, K., Fehervari, Z., Oida, T., Ogawa, O., and Sakaguchi, S. Differential control of alloantigen-specific regulatory T cells and effector T cells by anti-CD4 and other agents in establishing transplantation tolerance. Int.Immunol. 21:379-391, 2009

Yoshitomi, M., Koshiba, T., Haga, H., Li, Y., Zhao, X., Cheng, D., Miyagawa, A., Sakashita, H., Tsuruyama T., Ueda, M., Wood, K., Sakaguchi S., Manabe, T., Tanaka, K., and Uemoto, S. Requirement of protocol biopsy before and after complete cessation of immunosuppression following liver transplantation. Transplantation. 87:606-614, 2009

Sakihama T, Sato T, Iwanari H, Kitamura T, Sakaguchi S, Kodama T, Hamakubo T. A simple detection method for low-affinity membrane protein interactions by baculoviral display. PLoS ONE. 2008;3(12):e4024.

Satoda N, Shoji T, Wu Y, Fujinaga T, Chen F, Aoyama A, Zhang JT, Takahashi A, Okamoto T, Matsumoto I, Sakai H, Li Y, Zhao X, Manabe T, Kobayashi E, Sakaguchi S, Wada H, Ohe H, Uemoto S, Tottori J, Bando T, Date H, Koshiba T. Value of FOXP3 Expression in Peripheral Blood as Rejection Marker After Miniature Swine Lung Transplantation. J. Heart Lung Transplant. 27:1293-1301, 2008.

Wing, K., Onishi, Y., Prieto-Martin, P., Yamaguchi, T., Miyara, M., Fehervari, Z., Nomura, T., and Sakaguchi, S. CTLA-4 control over Foxp3+ regulatory T cell function. Science. 322:271-275, 2008.

Li, Y., Zhao, X., Cheng, D., Haga, H., Tsuruyama, T., Wood, K., Sakaguchi, S., Tanaka, K., Uemoto, S., and Koshiba, T. The presence of FOXP3 expressing T cells within grafts of tolerance human liver transplant recipients. Transplantation. 86:1837-1843,2008

Sharma, S., Dominguez, A. L., Manrique, S. Z., Cavallo, F., Sakaguchi, S., and Lustgarten, J. Systemic targeting of CpG-ODN to the tumor microenvironment with anti-neu-CpG hybrid molecule and T regulatory cell depletion induces memory responses in BALB-neuT tolerant mice. Cancer Res. 68:7530-7540, 2008.

Onishi, Y., Fehervari, Z., Yamaguchi, T., and Sakaguchi, S. Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation. Proc. Natl. Acad. Sci. USA. 29:10113-10118, 2008.

Sakaguchi, S., Yamaguchi, T., Nomura, T., and Ono, M. Regulatory T cells and immune tolerance. Cell. 133: 775-787, 2008.

Miyara, M., Sakaguchi, S. Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked Syndrome. Encyclopedia of Molecular Medicine. In press.

Fehervari, Z. and Sakaguchi, S. T lymphocytes: Regulatory. Nature Encyclopedia of Life Sciences. Wiley Interscience, 2008. Available at www.els.net.

Sakaguchi, S. Regulatory T cells in the past and for the future. Eur. J. Immunol. 38:901-937, 2008.

Sakaguchi S, Wing K, Miyara M. Regulatory T cells in brief history and perspective. Eur. J. Immunol. 37:S116-123, 2007.

\Sakaguchi S
, Powrie F. Emerging challenges in regulatory T cell function and biology. Science. 317:627-629, 2007.

Nagahama K, Nishimura E, Sakaguchi S. Induction of tolerance by adoptive transfer of treg cells. Methods Mol Biol. 380:431-42, 2007.

Ko, H. J., Kim, Y. J., Kim, Y. S., Chang, W. S., Ko, S. Y., Chang, S. Y., Sakaguchi, S., Kang, C. Y. A combination of chemoimmunotherapies can efficiently break self-tolerance and induce antitumor immunity in a tolerogenic murine tumor model. Cancer Res. 67:7477-7486, 2007.

Yamaguchi T, Hirota K, Nagahama K, Ohkawa K, Takahashi T, Nomura T, Sakaguchi S. Control of immune responses by antigen-specific regulatory T cells expressing the folate receptor. Immunity. 27:145-159, 2007.

Ono M, Yaguchi H, Ohkura N, Kitabayashi I, Nagamura Y, Nomura T, Miyachi Y, Tsukada T, Sakaguchi S. Foxp3 controls regulatory T cell function via interacting with AML1/Runx1. Nature. 446:685-689, 2007.

Nomura T, Sakaguchi S. Foxp3 and Aire in thymus-generated T(reg) cells: a link in self-tolerance. Nat Immunol. 8:333-334, 2007.

Miyara M, Sakaguchi S. Natural regulatory T cells: mechanisms of suppression. Trends Mol Med. 13:108-116, 2007.

Koshiba T, Li Y, Takemura M, Wu Y, Sakaguchi S, Minato N, Wood KJ, Haga H, Ueda M, Uemoto S. Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation. Transpl Immunol. 17:94-97, 2007.

Bodor J, Fehervari Z, Diamond B, Sakaguchi S. ICER/CREM-mediated transcriptional attenuation of IL-2 and its role in suppression by regulatory T cells. Eur J Immunol. 37:884-895, 2007.

Bodor J, Fehervari Z, Diamond B, Sakaguchi S. Regulatory T cell-mediated suppression: potential role of ICER. J Leukoc Biol. 81:161-167, 2007.

Sakaguchi, S.
: Regulatory T cells: meden agan. Immunol. Rev. 212:5-7.2006.

Lee SK, Choi BK, Kim YH, Kang WJ, Kim KH, Sakaguchi S, Suh JH, Kim TY, Kwon BS. Glucocorticoid-induced tumour necrosis factor receptor family-related receptor signalling exacerbates hapten-induced colitis by CD4+ T cells. Immunology. 119(4):479-87, 2006.

Yamaguchi T, Sakaguchi S. Skin controls immune regulators. Nat Med. 12:1358-1359, 2006.

Ramirez-Montagut T, Chow A, Hirschhorn-Cymerman D, Terwey TH, Kochman AA, Lu S, Miles RC, Sakaguchi S, Houghton AN, van den Brink MR. Glucocorticoid-Induced TNF Receptor Family Related Gene Activation Overcomes Tolerance/Ignorance to Melanoma Differentiation Antigens and Enhances Antitumor Immunity. J Immunol. 176:6434-6442, 2006.

Katakai T, Nomura T, Gonda H, Sugai M, Agata Y, Nishio A, Masuda T, Sakaguchi S, Shimizu A. Spontaneous Large-Scale Lymphoid Neogenesis and Balanced Autoimmunity versus Tolerance in the Stomach of H+/K+-ATPase-Reactive TCR Transgenic Mouse. J Immunol. 177:7858-67, 2006.

Cobb BS, Hertweck A, Smith J, O'connor E, Graf D, Cook T, Smale ST, Sakaguchi S, Livesey FJ, Fisher AG, Merkenschlager M. A role for Dicer in immune regulation. J Exp Med. 203:2519-2527, 2006.

Matsubara Y, Hori T, Morita R, Sakaguchi S, Uchiyama T.: Delineation of immunoregulatory properties of adult T-cell leukemia cells. Int. J. Hematol. 84:63-69, 2006.

Wing, K. and  Sakaguchi, S.: Regulatory T cells in allergy. Curr. Opin. Allergy and Immunol. 6:482-8, 2006.

Sakaguchi, S.: Introduction: Regulatory T cells. Springer Semin. Immunopathol. 28:1-2, 2006.

Fehervari, Z. and Sakaguchi, S.: Peacekeepers of the immune system. Sci Am. 295:56-63, 2006.

Wing, K., Fehervari, Z., and Sakaguchi, S.: Emerging possibilities in the development and function of regulatory T cells. Int. Immunol. 18:991-1000, 2006.


Sakaguchi, S., Ono, M., Setoguchi, R., Hori, S., Fehervari, Z., Shimizu, J., Takahashi, T., and Nomura, T.: Foxp3+CD25+CD4+ natural regulatory T cells in dominant self-tolerance and autoimmune disease. Immunol. Rev. 212:8-27,2006.


Nishioka, T., Shimizu, J, Iida, R., Yamazaki, S., and Sakaguchi, S.: CD4+CD25+Foxp3+ T cells and CD4+CD25-Foxp3+ T cells in aged mice. J. Immunol. 176:6586-6593, 2006.


Sugimoto, N., Oida, T., Hirota, K., Nakamura, K., Nomura, T., Uchiyama, T., and Sakaguchi, S.: Foxp3-dependent and -independent molecules specific for CD25+CD4+ natural regulatory T cells revealed by DNA microarray analysis. Int. Immunol. 18:1197-1209, 2006.

Wing, K., Fehervari, Z., and Sakaguchi, S.: Emerging possibilities in the development and function of regulatory T cells. Int. Immunol. 18:991-1000, 2006.

Cohen AD, Diab A, Perales MA, Wolchok JD, Rizzuto G, Merghoub T, Huggins D, Liu C, Turk MJ, Restifo NP, Sakaguchi S, Houghton AN. Agonist anti-GITR antibody enhances vaccine-induced CD8(+) T-cell responses and tumor immunity. Cancer Res. 66:4904-4912, 2006.


Kim, J., Choi, W. S, Kim, H. J., Suh, J-H., Sakaguchi, S., and Kwon B.: Conversion of alloantigen-specific CD8+ T-cell priming through in vitro ligation of glucocorticoid-induced TNF receptor. J. Immunol. 176:5223-5231, 2006.


Ono, M., Shimizu, J., Miyachi, Y., and Sakaguchi, S.: Induction of fatal autoimmune myocarditis and other autoimmune diseases in mice by depleting Foxp3-expressing naturally arising CD4+ regulatory T cells. J. Immunol. 176:4748-4756,2006.

Fehervari, Z., Yamaguchi, T., and Sakaguchi, S.: The dichotomous roles of IL-2: tolerance versus immunity. Trends Immunol. 27:109-111, 2006.

Yamaguchi, T. and Sakaguchi, S.: Regulatory T cells in immune surveillance and treatment of cancer. Semin. Cancer Biol. 16:115-123, 2006.

Sakaguchi, S., Setoguchi, R., Yagi, H., and Nomura, T.: Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in self-tolerance and autoimmune disease. Curr Top Microbiol Immunol. 305:51-66, 2006.

Fehervari, Z.and Sakaguchi, S.: T lymphocytes: Regulatory. Nature Encyclopedia of Life Sciences. Wiley Interscience, 2006. Available at www.els.net.

Yoshizawa, A., Ito, A., Li, Y., Koshiba, T., Sakaguchi, S., Wood, K. J., and Tanaka, K. The roles of CD25+CD4+ regulatory T cells in operational tolerance after living donor liver transplantation. Transplant. Proc. 37:37-39, 2005.

Ko, K., Yamazaki, S., Nakamura, K., Nishioka, T., Hirota, K., Yamaguchi, T., Shimizu, J., Nomura, T., Chiba, T., and Sakaguchi, S. Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J. Exp. Med. 202: 885-891, 2005.

Quezada SA, Bennett K, Blazar BR, Rudensky AY, Sakaguchi S, Noelle RJ: Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: the interplay of clonal anergy and immune regulation. J. Immunol. 175:771-779, 2005.

Nishikawa H, Kato T, Tawara I, Saito K, Ikeda H, Kuribayashi K, Allen PM, Schreiber RD, Sakaguchi S, Old LJ, Shiku H. Definition of target antigens for naturally occurring CD4+CD25+ regulatory T cells. J. Exp. Med. 201: 681-686, 2005.


Chai, J-G., Xue, S., Coe, D., Addey, C., Bartok, I., Scott, D., Simpson, E., Stauss, H. J., Hori, S., Sakaguchi, S., and Dyson, J. P. Regulatory T cells, derived from naive CD4+CD25- T cells by in vitro Foxp3 gene transfer, can induce transplantation tolerance. Transplantation.79:1310-1316, 2005.


Sakaguchi, S., and Sakaguchi, N.: History of CD25+CD4+ regulatory T cells. In Regulatory T cells in inflammation, Progress in Inflammation Research. Eds. L. S. Taams, A. N. Akbar, and M. H. M. Wauben, Birkhaeuser Verlag, Basel, p3-17, 2005.


Sakaguchi, S.: Preface: Regulatory T cells in autoimmune diseases. Int. Rev. Immunol.24:157-158,2005.


Sakaguchi, S. and Sakaguchi, N.: Regulatory T cells in self-tolerance and autoimmune diseases. Int. Rev. Immunol.24:211-226,2005.


Fehervari, Z. and Sakaguchi, S.: A common basis of self-tolerance and transplantation tolerance: a simple way of inducing transplantation tolerance with naturally arising CD25+CD4+ regulatory T cells. Philosophical Transactions: Biological Sciences.360:1647-1661,2005.


Sakaguchi, S.: Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nature Immunol. 6: 345-352, 2005.

Matsubara, Y., Hori, T., Morita, R., Sakaguchi, S., and Uchiyama, T.: Phenotypic and functional relationship between adult T cell leukemia and regulatory T cells. Leukemia 19:482-483, 2005.


Setoguchi, R., Hori, S., Takahashi, T., and Sakaguchi, S.: Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization J. Exp. Med. 201:723-735, 2005.


Gondek, D. C., Lu, L-F., Quezada, S. A., Sakaguchi, S., and Noelle, R. J. Cutting Edge: Contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J. Immunol.174: 1783-1786, 2005.


Kuroda N, Mitani T,Takeda N, Ishimura N, Arakaki R, Hayashi Y,Bando Y,  Izumi K, Takahashi T,Nomura T, Sakaguchi S, Ueno Y, Takahama Y, Uchida D, Sun S, Kajiura F, Mouri Y, Han H, Matushima A, Yamada G, Matumoto M. Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice. J. Immunol. 174:1862-1870, 2005


Nomura, T., and Sakaguchi, S.: Regulatory T cells in tumor immunity. Current Topics in Microbiology and Immunology.293:287-302, 2005.


Fehervari, Z., and Sakaguchi, S.:  Regulatory T cells. In "Measuring Immunity" eds. M. T. Lotze and A. W. Thompson, Elsevier.p322-335,2005.

Setoguchi, R., Hori, S., Takahashi, T., and Sakaguchi, S.: A crucial role of IL-2 in the homeostatic maintenance of CD25+CD4+ regulatory T cells. Immunology 2004. Medimond S.r.l., Bologna, Italy. p341-344, 2004.


Ono, M., Shimizu, J., Miyachi, Y., and Sakaguchi, S.: Induction of fatal autoimmune myocarditis and other autoimmune diseases in mice by depleting Foxp3-expressing T cells. Immunology 2004. Medimond S.r.l., Bologna, Italy. p193-195, 2004.


Turk MJ, Guevara-Patino JA, Rizzuto GA, Engelhorn ME, Sakaguchi S., and Houghton AN.: Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J. Exp. Med. 200:771-82, 2004


He, H., Messer, R.J., Sakaguchi, S., Yang, G., Robertson, S. J., and Hasenkrug, K. J. Reduction of retrovirus-induced immunosuppression by in vivo modulation of T cells during acute infection. J. Virology. 78:11641-7, 2004.


Muriglan, S. J., Ramirez-Montagut, T., Alpdogan, O., Van Huystee, T. W., Eng, J. M., Hubbard, V. M., Kochman, A. A., Tjoe, K. H., Riccardi, C., Pandolfi, P. P., Sakaguchi, S., Houghton, A. N., and Van Den Brink, M. R. GITR Activation induces an opposite effect on alloreactive CD4+ and CD8+ T cells in graft-versus-host disease. J. Exp. Med. 200(2):149-157, 2004.


Ying Li, Y., Koshiba, T., Yoshizawa, A., Yonekawa, Y., Ito, A., Mori, T., Kawamoto, H., Tanaka, Y., Sakaguchi, S., Minato, N., Wood, K. J., and Tanaka, K: Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation. American J. Transplantation. 4:2118-2125, 2004.


Fehervari, Z., and Sakaguchi, S.: CD4+ regualtory T cells and the control of immunity. J. Clin. Invest.114:1209-117,2004.


Takahata, Y., Nomura, A., Takada, H., Ohga, S., Furuno, K., Hikino, S., Nakayama, H., Sakaguchi, S., Hara, T.: CD25+CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene. Exp Hematol. 32:622-629, 2004.


Sakaguchi, S., Ko, K., Yamazaki, S., Nakamura, K., Hirota, K., and Nomura, T.: Regulatory T cells in tumor immunity. In Cancer Immunotherapy, edit. K. Toyoshima, J. C. Barrett, E. Klein, Y. Hashimoto, and H. Wakasugi. Princess Takamatsu Cancer Research Fund, Tokyo, P47-51, 2004.


Yagi, H., Nomura, T., Nakamura, K., Kitawaki, T., Hori, S., Maeda, M., Onodera, M., Uchiyama, T., Fujii, S., and Sakaguchi, S.: Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells. Int. Immunol. 16:1643-1656,2004.


Kanamaru, F., Youngnak, P., Hashiguchi, M., Nishioka, T., Takahashi, T., Sakaguchi, S., Ishikawa, I., and Azuma, M. Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. J. Immunol. 172:7306-7314,2004


Fehervari, Z., and Sakaguchi, S.: Control of CD25+CD4+ regulatory T cell activation and function by dendritic cells. Int. Immunol. 16:1769-1780,2004.


Nishimura, E., Sakihama, T., Setoguchi, R., Tanaka. K., and Sakaguchi, S.: Induction of allograft tolerance by in vivo and ex vivo antigen-specific expansion of Foxp3-expressing endogenous CD25+CD4+ regulatory T cells. Int. Immunol. 16:1189-1201,2004


Dittmer, U., He, H., Messer, R. J., Schimmer, S., Olbrich, A. R., Ohlen, C., Greenberg, P. D., Stromnes, I. M., Iwashiro, M., Sakaguchi, S., Evans, L. H., Peterson, K. E., Yang, G., Hasenkrug, K. J.: Functional impairment of CD8+ T cells by regulatory T cells during persistent retroviral infection. Immunity. 20: 1-20, 2004.


Suri, A., Shimizu, J., Katz, J. D., Sakaguchi, S., Unanue, E. R., and Kanagawa, O.: Regulation of autoimmune diabetes by non-islet-specific T cells - a role for the glucocorticoid-induced TNF receptor. Eur. J. Immunol. 34: 447-454, 2004.


Kajiura, F., S. Sun, T. Nomura, K. Izumi, T. Ueno, Y. Bando, N. Kuroda, H. Han, Yi Li, A. Matsushima, Y. Takahama, S. Sakaguchi, T. Mitani and M. Matsumoto. 2004. NF-kB-inducing kinase establishes self-tolerance in a thymic-stroma dependent manner. J. Immunol. 172: 2067-2075, 2004.


Hori, S., and Sakaguchi, S.: Foxp3, a critical regulator of regulatory T cell development and function. Microbes and Infection. 6: 745-51, 2004.


Choi, B. K., Bae, J. S., Choi, E. M., Kang, W. J., Sakaguchi, S., Vinay, D. S., and Kwon, B. S. 2003. 4-1BB-dependent inhibition of immunosuppression by activated CD4+CD25+ T cells. J. Leukoc. Biol. 75: 785-791, 2004.


 Sakaguchi, S.: Naturally arising CD4+ regulatory T cells for immunologic self-tolelance and negative control of immune responses. Ann. Rev. Immunol. 22:531-562, 2004.


Zhang, X., Koldzix, D.J., Izikson, L., Reddy, J., Nazareno, R. F., Sakaguchi, S., Kuchroo, V. K., and Weiner, H. L. IL-10 is involved in the suppression of experimental autoimmune encephalomyelitis by CD25+CD4+ regulatory T cells. Int. Immunology. 16: 1-8, 2004.


Fehervari, Z., and Sakaguchi, S.: Development and function of CD25+CD4+ regulatory T cells. Curr. Opinion in Immunol. 16:203-208, 2004.


Fehervari, Z. and Sakaguchi, S.: A paragon of self-tolerance:Regulatory T cells and the control of immune responses. Arthritis Res. Ther. 6: 19-25, 2004.


Sakaguchi, S.: Taming transplantation by regulatory T cells. Nature Medicine 9: 1117-1118, 2003.

Hori, S., Takahashi, T., and Sakaguchi, S. Control of autoimunity by natural regulatory T cells. Adv. Immunol. 81: 329-369, 2003.


Sakaguchi, S.: The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery. J. Clin. Invest. 112: 1310-1312, 2003


Takahashi, T. and Sakaguchi, S.: Naturally arising CD25+CD4+ regulatory T cells in maintaining immunologic self-tolerance and preventing autoimmune disease. Curr. Mol. Med. 3: 693-706, 2003.


Sakaguchi, S. Control of immune responses by naturally arising CD4+ regulatory T cells. J. Exp. Med. 197: 397-401, 2003.


Hori, S., Nomura, T., and Sakaguchi, S.: Control of regulatory T cell development by the transcription factor Foxp3. Science. 299: 1057-1061, 2003.


Wood, K. and Sakaguchi, S. Regulatory T cells in transplantation. Nature Rev. Immunol. 3: 199-210, 2003.


Sakaguchi, S. Regulatory T cells: mediating compromises between host and parasite. Nature Immunol. 4: 10-11, 2003.


Takahashi, T., and Sakaguchi, S.: The role of regulatory T cells in controlling immunologic self-tolerance. Int. Rev. Cytol. 225: 1-32, 2003.


Sakaguchi, S., Hori, S., Fukui, Y., Sasazuki, T., Sakaguchi, N., and Takahashi, T. Thymic generation and selection of CD25+CD4+ regulatory T cells: Implications of their broad repertoire and high self-reactivity for the maintenance of immunologic self-tolerance. Novartis Foundation Symposium. 252: 6-16; discussion 16-23, 106-14, 2003.


Wood, K. J., H. Ushigome, M. Karim, A. Bushell, H. S and S. Sakaguchi. Regulatory T cells in transplantation. Novartis Foundation Symposium. 252:177-88; discussion 188-93, 203-10, 2003

Sakaguchi, S.: Immunologic tolerance maintained by regulatory T cells:
Implications for autoimmunity, tumor immunity and transplantation tolerance.
Vox Sang 83: S151-S153, 2002.

Gallimore, A., and Sakaguchi, S.: Regulation of tumor immunity by CD25+ Tcells.
Immunology 107: 5-9, 2002.

Shimizu, J., Yamazaki, S., Takahashi, T., Ishida, Y., and Sakaguchi, S.: Immunologic self-
tolerance is broken by stimulating CD25+ CD4+ regulatory T cells through GITR, a TNF
receptor superfamily protein. Nature Immunol. 3: 135-142,2002.

Sakaguchi, S., Sakaguchi, N., Shimizu, J., Yamazaki, S., Sakihama. T., Itoh, M., Kuniyasu, Y.,
Nomura, T., Toda, M., and Takahashi, T.: Immunologic tolerance maintained by CD25+ CD4+
regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and
transplantation tolerance. Immunol. Rev. 182: 18-32, 2001.

Sakaguchi, S.: Regulation of immune responses. In Clinical Immmunology. 2 nd ed. R. R. Rich, T.
A. Fleisher, W. T. Shearer, H. W. Schraeder, Jr., and B. L. Kotzin (Eds). Mosby, London. p15.1-11,

Sakaguchi, S., Takahashi, T., Yamazaki, S., Kuniyasu, Y., Itoh, M., Sakaguchi, N., and Shimizu, J.:
Immunologic self-tolerance maintained by T cell-mediated control of self-reactive T cells:
implications for autoimmunity and tumor immunity. Microbes and Infection. 3: 911-918, 2001.

Sakaguchi, S.: Policing the regulators. Nature Immunol. 2: 283-284, 2001.

Kumanogoh, A., Wang, X., Lee, I., Watanabe, C., Shi, W., Yoshida, K., Habu, S., Itoh, M., Sakaguchi,
N., Sakaguchi, S., Sand Kikutani, H.: Increased T-cell autoreactivity in the absence of CD40-
CD40 ligand interactions: A role of CD40 in regulatory T cell development. J. Immunol.166:
353-360, 2001.



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